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24 reviewsabstractArticle history:Introduction: As a member of annexin family proteins, annexin A3 (ANXA3) has 36-kDa and 33-kDa isoReceived 2 May 2020forms. ANXA3 plays crucial roles in the tumorigenesis, aggressiveness and drug-resistance of cancers.Revised 30 October 2020However, previous studies mainly focused on the role of total ANXA3 in cancers without distinguishingAccepted 4 November 2020the distinction between the two isoforms, the role of 33-kDa ANXA3 in cancer remains unclear.Available online xxxxObjectives: Current work aimed to investigate the function and regulation mechanism of 33-kDa ANXA3Keywords:in hepatocarcinoma.Methods: The expressions of ANXA3, CRKL, Rac1, c-Myc and pAkt were analyzed in hepatocarcinomaHepatocarcinomaspecimens by Western blotting. The biological function of 33-kDa ANXA3 in the growth, metastasis,33-kDa ANXA3apoptosis, angiogenesis, chemoresistance of hepatocarcinoma cells with the underlying molecular mechTumorigenesisanism were investigated using gain-of-function strategy in vitro or in vivo.Peer review under responsibility of Cairo University.Production and hosting by Elsevier⇑ Corresponding authors at: Department of Biochemistry, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian,Liaoning 116044, China (S.Q. Liu). Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian,Liaoning 116044, China (M.Z. Sun).E-mail addresses: [email protected] (S. Liu), [email protected] (M.-Z. Sun). 1 These authors contributed equally. 2020 THE AUTHORS. Published by Elsevier BV on behalf of Cairo University.This is an open access article under the CC BY-NC-ND license ( cite this article as: C. Guo, N. Li, C. Dong et al., 33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF andintrinsic apoptosis pathways, Journa
