logo
0

EbookBell.com

Most ebook files are in PDF format, so you can easily read them using various software such as Foxit Reader or directly on the Google Chrome browser.
Some ebook files are released by publishers in other formats such as .awz, .mobi, .epub, .fb2, etc. You may need to install specific software to read these formats on mobile/PC, such as Calibre.

Please read the tutorial at this link:  https://ebookbell.com/faq 


We offer FREE conversion to the popular formats you request; however, this may take some time. Therefore, right after payment, please email us, and we will try to provide the service as quickly as possible.


For some exceptional file formats or broken links (if any), please refrain from opening any disputes. Instead, email us first, and we will try to assist within a maximum of 6 hours.

EbookBell Team

A Singlemolecule Pleuripotent Scaffold For Combinational Therapy Of Alzheimers Disease Via Intranasal Administration Jianmei Gao

  • SKU: BELL-238460470
A Singlemolecule Pleuripotent Scaffold For Combinational Therapy Of Alzheimers Disease Via Intranasal Administration Jianmei Gao
$ 35.00 $ 45.00 (-22%)

4.4

42 reviews

A Singlemolecule Pleuripotent Scaffold For Combinational Therapy Of Alzheimers Disease Via Intranasal Administration Jianmei Gao instant download after payment.

Publisher: x
File Extension: PDF
File size: 3.77 MB
Pages: 15
Author: Jian-Mei Gao, Wen-Bo Li, Na-Na Chen, Yang Yi, Ze-Han Wang, Xian Chen, Yang-Yang Zhao, Ze-Li Yuan, Jie Gao, Yu-Chen Pan, Dong-Sheng Guo, * Qi-Hai Gong*
ISBN: 10.1002/ADVS.202511611
Language: English
Year: 2025
Volume: e11611

Product desciption

A Singlemolecule Pleuripotent Scaffold For Combinational Therapy Of Alzheimers Disease Via Intranasal Administration Jianmei Gao by Jian-mei Gao, Wen-bo Li, Na-na Chen, Yang Yi, Ze-han Wang, Xian Chen, Yang-yang Zhao, Ze-li Yuan, Jie Gao, Yu-chen Pan, Dong-sheng Guo, * Qi-hai Gong* 10.1002/ADVS.202511611 instant download after payment.

The intricate pathological mechanisms of Alzheimer’s disease (AD), along with the restrictive nature of the blood-brain barrier (BBB) that further impedes the drug brain entry, underscore the pressing need for innovative combinational therapy to achieve effective treatment outcomes. Intranasal administration, capable of bypassing BBB by direct transport through olfactory and trigeminal nerves, provides a promising approach for treating neurological disorders. Herein, the guanidinium-modified calix[5]arene (GC5AY) is developed as a single-molecule pleuripotent scaffold, demonstrating small size, positive charge and desirable amphiphilicity, which facilitate its efficient traverse of nasal mucosal barrier. The multifunctionality of GC5AY, including inhibiting amyloid fibrosis, scavenging reactive oxygen species and drug delivery, enables it to serve as a sophisticated platform for constructing multi-target AD therapeutic agents. In light of this, by loading neuroprotective agent Trilobatin (TLB) into the cavity of GC5AY, intranasal administration of the TLB@GC5AY formulation is verified to effectively attenuate the cognitive impairment of AD mice, demonstrating multifaceted pathological improvements, while also possessing good biocompatibility. In response to the growing appeal for combinational therapy of AD, the approach proposed in this study has provided a readily generalizable strategy to fulfill this pursuit.

Related Products

Readout And Coherent Manipulation Of An Isolated Nuclear Spin Using A Singlemolecule Magnet Spintransistor 1st Edition Stefan Thiele Auth
-22%
Readout And Coherent Manipulation Of An Isolated Nuclear Spin Using A Singlemolecule Magnet Spintransistor 1st Edition Stefan Thiele Auth

4.4

32 reviews
$45.00 $35.00
Singlemolecule Biophysics Experiment And Theory Volume 146 Stuart A Rice
-22%
Singlemolecule Biophysics Experiment And Theory Volume 146 Stuart A Rice

4.8

54 reviews
$45.00 $35.00
Single Molecule Mechanics On A Surface Gears Motors And Nanocars Francesca Moresco
-22%
Single Molecule Mechanics On A Surface Gears Motors And Nanocars Francesca Moresco

4.4

72 reviews
$45.00 $35.00
Singlemolecule Fluorescence Spectroscopy Of The Folding Of A Repeat Protein 1st Edition Sharona Cohen Auth
-22%
Singlemolecule Fluorescence Spectroscopy Of The Folding Of A Repeat Protein 1st Edition Sharona Cohen Auth

5.0

38 reviews
$45.00 $35.00
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativityand Will Determine The Fate Of The Human Race Daniel Z Lieberman Michael E Long
-22%
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativityand Will Determine The Fate Of The Human Race Daniel Z Lieberman Michael E Long
$45.00 $35.00
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativity Daniel Z Lieberman
-22%
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativity Daniel Z Lieberman
$45.00 $35.00
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativityand Will Determine The Fate Of The Human Race Daniel Z Lieberman Michael E Long
-22%
The Molecule Of More How A Single Chemical In Your Brain Drives Love Sex And Creativityand Will Determine The Fate Of The Human Race Daniel Z Lieberman Michael E Long

5.0

108 reviews
$45.00 $35.00
Design And Control Of Highly Conductive Singlemolecule Junctions A Focus On The Metalmolecule Interface 1st Edition Satoshi Kaneko Auth
-22%
Design And Control Of Highly Conductive Singlemolecule Junctions A Focus On The Metalmolecule Interface 1st Edition Satoshi Kaneko Auth

4.3

58 reviews
$45.00 $35.00
Singlemolecule Livecell Rna Imaging With Crisprcsm Chenglong Xia David Colognori Xueyang Stephen Jiang Ke Xu Jennifer A Doudna
-22%
Singlemolecule Livecell Rna Imaging With Crisprcsm Chenglong Xia David Colognori Xueyang Stephen Jiang Ke Xu Jennifer A Doudna

4.3

48 reviews
$45.00 $35.00