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0 reviewsDrug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation. The advent of artifcial intelligence (AI) technologies, particularly emerging large language models and generative AI, is poised to redefne this paradigm. The integration of AI-driven methodologies into the drug development pipeline has already heralded subtle yet meaningful enhancements in both the efciency and efectiveness of this process. Here we present an overview of recent advancements in AI applications across the entire drug development workfow, encompassing the identifcation of disease targets, drug discovery, preclinical and clinical studies, and post-market surveillance. Lastly, we critically examine the prevailing challenges to highlight promising future research directions in AI-augmented drug development.
