Coordinated Hippocampalentorhinal Representations Support Human Contextdependent Spatial Navigation Pengcheng Lv by Pengcheng Lv, Dong Chen, Chao Zhang, Wei Duan & Pingping Lu, Kai Zhang, Liang Wang 10.1371/JOURNAL.PBIO.3003398 instant download after payment.

Abstract To execute goal-directed behavior, retrieval of both context and object information is crucial. Despite the ubiquity of such contextual computations in daily navigation, the OPEN ACCESSneural mechanisms underlying this process in humans and its connection to behavCitation: Lv P, Chen D, Zhang C, Duan W, ior remain largely elusive. Leveraging intracranial electroencephalography (iEEG) Lu P, Zhang K, et al. (2025) Coordinated recorded from epilepsy patients (N=31) engaged in a context-dependent spatial navhippocampal–entorhinal representations igation task, we uncovered distinct oscillatory patterns in the hippocampus (HC) and support human context-dependent spatial entorhinal cortex (EC) that represented context and object information, respectively. navigation. PLoS Biol 23(9): e3003398. the covariation of these neural representations predicted behavioral perforAcademic Editor: Simon Hanslmayr, University mance. Furthermore, both representations were primarily driven by low-frequency of Glasgow, UNITED KINGDOM OF GREAT oscillations (2–8 Hz). The synchronization of low-frequency oscillations between BRITAIN AND NORTHERN IRELANDHC and EC was associated with enhanced object representations in the EC. These Received: February 27, 2025findings highlight the importance of low-frequency neural dynamics in mediating both Accepted: September 3, 2025local representations and interregional interactions within the hippocampal–entorhinal Published: September 17, 2025circuit during context-dependent spatial navigation.Copyright: © 2025 Lv et al. This is an open