ESMO Handbook on Principles of Translational Research 1st Edition by Hakan Mellstedt ISBN 0415410916 9780415410915 by Hakan Mellstedt, Dirk Schrijvers, Dimitrios Bafaloukos, Richard Griel 0415410916 instant download after payment.
ESMO Handbook on Principles of Translational Research 1st Edition by Hakan Mellstedt - Ebook PDF Instant Download/Delivery: 0415410916, 9780415410915
Full download ESMO Handbook on Principles of Translational Research 1st Edition after payment
Product details:
ISBN 10: 0415410916
ISBN 13: 9780415410915
Author: Hakan Mellstedt
ESMO Handbook on Principles of Translational Research 1st Table of contents:
Part I: Fundamental Principles and Concepts
Chapter 1: Principles of Normal Cell Biology
- Cell Structure and Function
- Cell Cycle Regulation
- Protein Metabolism and Signaling Pathways
- Key Cellular Processes Relevant to Cancer (e.g., DNA repair, apoptosis)
Chapter 2: Principles of Tumor Biology
- Hallmarks of Cancer (Growth signals, insensitivity to anti-growth signals, limitless replicative potential, evading apoptosis, angiogenesis, tissue invasion and metastasis)
- Genetic and Epigenetic Alterations in Cancer
- Tumor Heterogeneity and Evolution
- The Tumor Microenvironment
Chapter 3: Principles of Immunology and Tumor Immunology
- Overview of the Innate and Adaptive Immune System
- Immune Surveillance Theory
- Tumor Antigens and Immunogenicity
- Mechanisms of Immune Evasion by Cancer Cells
- Principles of Cancer Immunotherapy
Part II: Tools and Methodologies in Translational Research
Chapter 4: Preclinical Models in Oncology Translational Research
- In Vitro Models (Cell Lines, 3D Cultures, Organoids)
- In Vivo Models (Patient-Derived Xenografts (PDX), Genetically Engineered Mouse Models (GEMMs))
- Advantages, Limitations, and Predictive Value of Different Models
- Ethical Considerations in Preclinical Research
Chapter 5: Biomarkers in Oncology
- Definition and Classification of Biomarkers (Prognostic, Predictive, Pharmacodynamic, Monitoring)
- Types of Biomarkers (Molecular, Protein, Imaging, Liquid Biopsy)
- Biomarker Discovery and Validation Strategies
- Clinical Application and Limitations of Biomarkers
Chapter 6: Molecular Diagnostics and Technologies
- Genomic Technologies (NGS, RNA-seq, Whole-Exome/Genome Sequencing)
- Proteomics and Metabolomics
- Single-Cell Technologies
- Imaging Modalities (PET, MRI, CT) for Translational Research
- Bioinformatics and Data Analysis in Multi-Omics Research
Chapter 7: New Drug Development
- Phases of Drug Development (Discovery to Clinical Trials)
- Conventional Anticancer Drug Development
- Development of Targeted Anticancer Agents
- Repurposing Existing Drugs
- Role of Biomarkers in Drug Development and Patient Selection
Part III: Clinical Translation and Beyond
Chapter 8: Clinical Trial Design in Translational Oncology
- Phases of Clinical Trials (Phase 0, I, II, III)
- Adaptive Trial Designs and Basket/Umbrella Trials
- Incorporating Biomarkers into Clinical Trial Design
- Ethical Considerations and Regulatory Aspects of Clinical Trials
Chapter 9: Targeted Therapies and Mechanisms of Action
- Receptor Tyrosine Kinase Inhibitors
- Monoclonal Antibodies
- Small Molecule Inhibitors of Signaling Pathways
- Immune Checkpoint Inhibitors
- Antibody-Drug Conjugates (ADCs) and Cell Therapies (CAR-T)
Chapter 10: Advanced Therapeutic Modalities
- Gene Therapy Approaches in Oncology
- Oncolytic Viruses
- Cancer Vaccines
- Combination Treatments and Rational Drug Design
Chapter 11: Safety and Toxicity of Novel Therapies
- Unique Toxicity Profiles of Targeted Agents and Immunotherapies
- Management of Treatment-Related Adverse Events
- Long-Term Side Effects and Survivorship Issues
Chapter 12: Pharmacodynamics and Pharmacokinetics
- Understanding Drug Absorption, Distribution, Metabolism, and Excretion (ADME)
- Measuring Drug Activity and Target Engagement
- Biomarkers for Pharmacodynamic Assessment
Chapter 13: Integrating Translational Research into Clinical Practice
- The Multidisciplinary Team Approach
- Molecular Tumor Boards and Personalized Medicine
- Challenges in Implementation and Access to Novel Therapies
- The Role of Real-World Evidence
Conclusion: The Future of Translational Oncology
- Emerging Technologies and Future Directions
- Addressing Unmet Needs in Cancer Treatment
- The Importance of Collaboration and Global Initiatives
- Continual Learning in Translational Research
People also search for ESMO Handbook on Principles of Translational Research 1st:
esmo handbook on principles of translational
esmo handbook of translational research
esmo practice guidelines
esmo presentation
esmo guidelines hnscc
Tags: Hakan Mellstedt, ESMO, Handbook
