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0 reviewsSUMMARYThe combined effects of aging and cancer on immune cells were investigated in young versus aged miceharboring B cell lymphoma, and in T cells from young and aged B cell lymphoma patients. These analysesrevealed that lymphoma alone is sufficient to trigger transcriptional, epigenetic, and phenotypic alterationsin young T cells that manifest in aged T cells. In contrast, aged T cells are largely resistant to lymphomainduced changes. Pathway analyses revealed open chromatin regions and genes controlling iron homeostasis are induced by both lymphoma and aging, and lymphoma-experienced and aged T cells have increasediron pools and are resistant to ferroptosis. Furthermore, both aged and lymphoma-experienced T cells havedefects in proteostasis. B cell lymphoma also accelerates aging of other tissues, as evidenced by elevatedexpression of Cdkn2a and Tnfa. Finally, some lymphoma-induced aging phenotypes are reversible whereasothers are fixed, indicating opportunities for improving some cancer-associated aging comorbidities.
