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Protein Folding Protocols Methods in Molecular Biology Vol 350 1st Edition by Yawen Bai, Ruth Nussinov ISBN 1588296229 978-1588296221

  • SKU: BELL-2016044
Protein Folding Protocols Methods in Molecular Biology Vol 350 1st Edition by Yawen Bai, Ruth Nussinov ISBN 1588296229 978-1588296221
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Protein Folding Protocols Methods in Molecular Biology Vol 350 1st Edition by Yawen Bai, Ruth Nussinov ISBN 1588296229 978-1588296221 instant download after payment.

Publisher: Springer
File Extension: PDF
File size: 3.72 MB
Pages: 344
Author: Yawen, Ed. Bai
ISBN: 9781588296221, 9781597451895, 1588296229, 1597451894
Language: English
Year: 2006
Edition: 1

Product desciption

Protein Folding Protocols Methods in Molecular Biology Vol 350 1st Edition by Yawen Bai, Ruth Nussinov ISBN 1588296229 978-1588296221 by Yawen, Ed. Bai 9781588296221, 9781597451895, 1588296229, 1597451894 instant download after payment.

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Product details:

ISBN 10: 1588296229

ISBN 13: 978-1588296221 

Author: Yawen Bai, Ruth Nussinov

Protein Folding Protocols presents protocols for studying and characterizing steps and conformational ensembles populating pathways in protein folding from the unfolded to the folded state. It further presents a sample of approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. Protein folding is a crucial step in the transfer of genetic information from the DNA to the protein. The Genome Project has led to a huge number of available DNA sequences and, therefore, protein sequences. The Structural Genomics initiative largely aims to obtain “new” folds not currently present in the Protein Data Bank. Yet, the number of available structures inevitably lags behind the number of sequences. At the same time, an equally important problem is to find out the types and scope of dissimilar (nonhomologous) protein sequences that adopt a similar fold. Assembling data and comprehension of the sequence space of protein folds should be very useful in computational protein structure prediction. This would enhance the scope of homology modeling, which currently is the method of choice. Thus, experimental and theoretical studies on the relationship between sequence and structure are critical. Figuring out the relationship between sequence and structure would further assist in the prediction of fibril structures observed in protein misfolding diseases, and in figuring out the conformational changes and dynamics resulting from mutations. Protein folding is one of the most important and challenging problems in current molecular and chemical biology.

Table of contents:

1. Infrared Temperature-Jump Study of the Folding Dynamics of α-Helices and β-Hairpins
2. The Use of High-Pressure Nuclear Magnetic Resonance to Study Protein Folding
3. Characterization of Denatured Proteins Using Residual Dipolar Couplings
4. Characterizing Residual Structure in Disordered Protein States Using Nuclear Magnetic Resonance
5. Population and Structure Determination of Hidden Folding Intermediates by Native-State Hydrogen Exchange-Directed Protein Engineering and Nuclear Magnetic Resonance
6. Characterizing Protein Folding Transition States Using Ψ-Analysis
7. Advances in the Analysis of Conformational Transitions in Peptides Using Differential Scanning Calorimetry
8. Application of Single Molecule Förster Resonance Energy Transfer to Protein Folding
9. Single Molecule Studies of Protein Folding Using Atomic Force Microscopy
10. Using Triplet-Triplet Energy Transfer to Measure Conformational Dynamics in Polypeptide Chains
11. A Hierarchical Protein Folding Scheme Based on the Building Block Folding Model
12. Replica Exchange Molecular Dynamics Method for Protein Folding Simulation
13. Estimation of Folding Probabilities and Φ Values From Molecular Dynamics Simulations of Reversible Peptide Folding
14. Packing Regularities in Biological Structures Relate to Their Dynamics
15. Intermediates and Transition States in Protein Folding
16. Thinking the Impossible
17. Back Matter

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Tags: Yawen Bai, Ruth Nussinov, Protein Folding, Protocols, Methods, Molecular Biology, Volume 350

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