Restoration Of Temporal Separability Between Betaand Movement Ensemble Cofiringwith Motor Recovery Hoseok Choi Jaekyung Kim Preeya Khanna Sandon Griffin Lisa Novik Robert J Morecraft John H Morrison Karunesh Ganguly by Hoseok Choi & Jaekyung Kim & Preeya Khanna & Sandon Griffin & Lisa Novik & Robert J. Morecraft & John H. Morrison & Karunesh Ganguly instant download after payment.

SUMMARYStroke disrupts movement control by damaging descending motor pathways, yet the cortical dynamics underlying recovery remain poorly defined. Using a non-human primate model of primary motor cortex injurywith impaired reach-to-grasp control, we examined how dorsal premotor cortex (PMd) activity supports recovery. Specifically, we studied the interaction between beta activity (12–30 Hz), often linked to ‘‘idle’’ states,and execution-related ensemble co-firing quantified with dimensionality reduction. Stroke impaired the temporal separability between beta bursts and movement-related co-firing, leading to slower reaction times andreduced performance. Recovery was associated with increased separability, and during grasping, beta activity progressively declined with recovery. These results indicate that reliable transitions between high-betaidle and high co-firing execution states are important for movement control, whereas pathological beta intrusions during execution degrade performance. Importantly, low-frequency alternating current stimulation(ACS) via a ringtrode interface enhanced temporal separability and improved reach-to-grasp performance,highlighting a potential therapeutic strategy.