Singlecell Rna Sequencing To Identify Cellular Heterogeneity And Targets In Cardiovascular Diseases From Bench To Bedside Xinjie Xu Xiumeng Hua by Xinjie Xu. Xiumeng Hua, Han Mo, Shengshou Hu, Jiangping Song 10.1007/S00395-022-00972-1 instant download after payment.

Basic Research in Cardiology,AbstractThe mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-cell RNA sequencing (scRNAseq) has enabled the profling of single-cell transcriptomes at unprecedented resolution and throughput, which is critical for deciphering cardiovascular cellular heterogeneity and underlying disease mechanisms, thereby facilitating the development of therapeutic strategies. In this review, we summarize cellular heterogeneity in cardiovascular homeostasis and diseases as well as the discovery of potential disease targets based on scRNA-seq, and yield new insights into the promise of scRNA-seq technology in precision medicine and clinical application.Keywords Single-cell RNA sequencing (scRNA-seq) · Cellular heterogeneity · Disease targets · Cardiovascular diseases · Precision medicine · Clinical application · Immunotherapy development