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4.8
94 reviewsSUMMARYEpithelial tissues serve as the first line of host against bacterial infections. The self-organization of epithelialtissues continuously adapts to the architecture and mechanics of microenvironments, thereby dynamicallyimpacting the initial niche of infections. However, the mechanism by which tissue geometry regulates bacterial infection remains poorly understood. Here, we showed geometry-guided infection patterns of bacteria inepithelial tissues using bioengineering strategies. We discovered that cellular traction forces play a crucialrole in the regulation of bacterial invasive sites and marginal infection patterns in epithelial monolayersthrough triggering co-localization of mechanosensitive ion channel protein Piezo1 with bacteria. Further,we developed precise mechanobiology-based strategies to potentiate the antibacterial efficacy in animalmodels of wound and intestinal infection. Our findings demonstrate that tissue geometry exerts a key impacton mediating spatiotemporal infections of bacteria, which has important implications for the discovery anddevelopment of alternative strategies against bacterial infections.
