Vagal Blockade Of The Brainliver Axis Deters Cancerassociated Cachexia Aliesha Garrett by Aliesha Garrett instant download after payment.

SUMMARYCancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearlyone-third of cancer-related deaths. It contributes to therapy resistance and increases mortality amongaffected patients. In this study, we show that cancer-induced systemic inflammation alters vagal tone inCAC mouse models. This vagal dysregulation disrupts the brain-liver vagal axis, leading to a reprogrammingof hepatic protein metabolism through the depletion of HNF4α, a key transcriptional regulator of liver function. The loss of HNF4α disrupts hepatic metabolism and promotes systemic inflammation, resulting incachectic phenotypes. Interventions targeting the right cervical vagus nerve surgically, chemically, electrically, or through a non-invasive transcutaneous device attenuate CAC progression, alleviate its clinicalmanifestations, and synergize with chemotherapy to improve overall health and survival in mice.