Voltagegated Ion Channels As Drug Targets Edited By David J Triggle Et Al by Edited By David J. Triggle ... [et Al.]. instant download after payment.

1 online resource (xii, 479 pages) :, Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion cha, Includes bibliographical references and index, Introduction : on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng -- The voltage-gated ion channel superfamily / William A. Catterall -- State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P. Bean -- Assay technologies : techniques available for quantifying drug-channel interactions / Derek Leishman, Gareth Waldron -- Overview of voltage-gated calcium channels / Clinton Doering, Gerald Zamponi -- Drugs active at T-type Ca² channels / Thomas M. Connolly, James C. Barrow -- L-type calcium channels / David J. Triggle -- N-type calcium channels -- Molecular, biophysical and functional properties of voltage-gated sodium channels / Douglas S. Krafte, Mark Chapman, Ken McCormack -- Small molecule blockers of voltage-gated sodium channels / Jesús E. González, Andreas P. Termin, Dean M. Wilson -- Potassium channels : overview of molecular, biophysical and pharmacological properties / Murali Gopalakrishnan, Char-Chang Shieh, Jun Chen -- Kv1.3 potassium channel : physiology, pharmacology and therapeutic indications / K. George Chandy, Heike Wulff, Christine Beeton, Peter A. Calabresi, George A. Gutman, Michael Pennington -- Drugs active at kv1.5 potassium channels / Stefan Peukert, Heinz Gögelein -- Medicinal chemistry of Ca²-activated K…