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EbookBell Team
4.7
76 reviewsISBN 10: 0387351345
ISBN 13: 9780387351346
Author: Sangram S Sisodia, Rudolph E Tanzi
This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.
The Genetics of Alzheimer’s Disease
APP Biology, Processing and Function
The Biology of the Presenilin Complexes
β-Secretase: Physiological Role and Target Validation
Cognitive Impairment in Transgenic Aβ and Tau Models of Alzheimer’s Disease
Cholesterol and β-Amyloid
Aβ Structure and Aggregation
Signaling Mechanisms that Mediate Aβ Induced Neuronal Dysfunction
Beta Amyloid and Excitatory Synapses
Aβ Degradation
Role of Aβ Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease
Tau Gene Mutations in FTDP-17 Syndromes
Animal Models of Tauopathy
Tau and Axonal Transport
Growth Factors in Alzheimer’s Disease
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Tags: Sangram S Sisodia, Rudolph E Tanzi, Disease, Molecular