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Aromatase Inhibitors Milestones in Drug Therapy 1st Edition by Barrington J A Furr ISBN 3764371994 978-3764371999

  • SKU: BELL-2196382
Aromatase Inhibitors Milestones in Drug Therapy 1st Edition by Barrington J A Furr ISBN 3764371994 978-3764371999
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Aromatase Inhibitors Milestones in Drug Therapy 1st Edition by Barrington J A Furr ISBN 3764371994 978-3764371999 instant download after payment.

Publisher: Birkhäuser Basel
File Extension: PDF
File size: 1.52 MB
Pages: 194
Author: A. Brodie, A. Buzdar, J. M. Dixon, P. E. Lonning, W. R. Miller, R. Paridaens, E. R. Simpson, A. E. W
ISBN: 9783764386924, 9783764386931
Language: English
Year: 2008
Edition: 2nd

Product desciption

Aromatase Inhibitors Milestones in Drug Therapy 1st Edition by Barrington J A Furr ISBN 3764371994 978-3764371999 by A. Brodie, A. Buzdar, J. M. Dixon, P. E. Lonning, W. R. Miller, R. Paridaens, E. R. Simpson, A. E. W 9783764386924, 9783764386931 instant download after payment.

Aromatase Inhibitors (Milestones in Drug Therapy) 1st Edition by Barrington J. A. Furr - Ebook PDF Instant Download/Delivery: 3764371994, 978-3764371999

Full download Aromatase Inhibitors (Milestones in Drug Therapy) 1st Edition after payment

 

 

Product details:

ISBN 10: 3764371994 

ISBN 13: 978-3764371999

Author: Barrington J. A. Furr

Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase).Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

Table of contents:

  1. Front Matter

  2. Background and development of aromatase inhibitors

  3. Aromatase inhibitors and models for breast cancer

  4. Clinical pharmacology of aromatase inhibitors

  5. Clinical studies with exemestane

  6. Clinical studies with letrozole

  7. Clinical studies with anastrozole

  8. The third-generation aromatase inhibitors: a clinical overview

  9. Lessons from the ArKO mouse

  10. Possible additional therapeutic uses of aromatase inhibitors

  11. Back Matter

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Tags: Barrington J A Furr, Aromatase, Inhibitors, Milestones, Drug, Therapy

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