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Astrocytemediated Central Amygdala Microcircuit Gates Comorbid Anxiety Symptoms In Chronic Pain Guiying Zan Songyu Yao Yingzhi Deng Yunhao Jiang Rufeng Ye Yexiang Chen Jiandong Long Yingjie Cheng Jingrui Chai Chi Xu Min Zhao Zhiqiang Liu Jinggen Liu Yujun Wang

  • SKU: BELL-239420500
Astrocytemediated Central Amygdala Microcircuit Gates Comorbid Anxiety Symptoms In Chronic Pain Guiying Zan Songyu Yao Yingzhi Deng Yunhao Jiang Rufeng Ye Yexiang Chen Jiandong Long Yingjie Cheng Jingrui Chai Chi Xu Min Zhao Zhiqiang Liu Jinggen Liu Yujun Wang
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Astrocytemediated Central Amygdala Microcircuit Gates Comorbid Anxiety Symptoms In Chronic Pain Guiying Zan Songyu Yao Yingzhi Deng Yunhao Jiang Rufeng Ye Yexiang Chen Jiandong Long Yingjie Cheng Jingrui Chai Chi Xu Min Zhao Zhiqiang Liu Jinggen Liu Yujun Wang instant download after payment.

Publisher: x
File Extension: PDF
File size: 45.57 MB
Author: Gui-Ying Zan & Song-Yu Yao & Ying-Zhi Deng & Yun-Hao Jiang & Ru-Feng Ye & Yexiang Chen & Jian-Dong Long & Ying-Jie Cheng & Jing-Rui Chai & Chi Xu & Min Zhao & Zhi-Qiang Liu & Jing-Gen Liu & Yu-Jun Wang
Language: English
Year: 2025

Product desciption

Astrocytemediated Central Amygdala Microcircuit Gates Comorbid Anxiety Symptoms In Chronic Pain Guiying Zan Songyu Yao Yingzhi Deng Yunhao Jiang Rufeng Ye Yexiang Chen Jiandong Long Yingjie Cheng Jingrui Chai Chi Xu Min Zhao Zhiqiang Liu Jinggen Liu Yujun Wang by Gui-ying Zan & Song-yu Yao & Ying-zhi Deng & Yun-hao Jiang & Ru-feng Ye & Yexiang Chen & Jian-dong Long & Ying-jie Cheng & Jing-rui Chai & Chi Xu & Min Zhao & Zhi-qiang Liu & Jing-gen Liu & Yu-jun Wang instant download after payment.

Neuron, Corrected proof. doi:10.1016/j.neuron.2025.09.004

SUMMARYComorbid anxiety symptoms are prominent affective components of chronic pain, yet the central mechanisms underlying these symptoms remain elusive. The central amygdala (CeA) regulates nociceptive processing and associated anxiety in chronic pain. However, the specific microcircuits and cell types withinthe CeA that regulate pain-related anxiety have not been fully elucidated. In this study, we discovered amicrocircuit in the CeA wherein dynorphinergic neurons of the lateral subdivision of the central amygdala(CeL) project to the medial subdivision (CeM), activation of which gates anxiogenic effects associated withchronic pain. Dynorphin-mediated activation of CeM astroglial kappa opioid receptors (KORs), dependentupon corticotropin-releasing factor (CRF) receptor 2 signaling, enhanced CeM neuron excitability bypromoting N-methyl-D-aspartate receptor (NMDAR) activation, likely via releasing gliotransmitter D-serine.Behaviorally, KOR-mediated bidirectional communication between CeA peptidergic neurons and astrocytesmodulates the anxiogenic effect of chronic pain. Our findings reveal a neuroglial microcircuit underlying painassociated anxiety and suggest potential targets for therapeutic intervention.