Asymmetric Synthesis Of Bioactive Lactones And The Development Of A Catalytic Asymmetric Synthesis Of Aryl Ketones 1st Edition Robert Doran Auth by Robert Doran (auth.) 9783319205434, 3319205439 instant download after payment.

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.