Bacterial Flora in Digestive Disease Focus on Rifaximin 1st Edition by C Scarpignato, A Lanas ISBN 3805580835 978-3805580830 by C. Scarpignato, A. Lanas 3805580835 instant download after payment.

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Product details:

ISBN 10:  3805580835

ISBN 13: 978-3805580830 

Author:  C. Scarpignato, A. Lanas 

Hundreds of bacterial species make up human gut flora. The intestine has at least 400 different species of bacteria totaling over 1012 organisms. Of these, 99% are anaerobic bacteria. The gastrointestinal tract is then exposed to countless numbers of bacterial species and foreign antigens and has embedded a unique and complex network of immunological and non-immunological mechanisms to protect the host from potentially harmful pathogens. Healthy individuals are generally tolerant to their own microbiota, but such tolerance is impaired in patients with both organic and functional gastrointestinal diseases. The advancement of the knowledge on microbial-gut interactions in health and disease has allowed a more pathophysiologically-oriented approach to several challenging clinical conditions. There are currently two ways to manipulate enteric flora. Antibiotics can selectively decrease tissue invasion and eliminate aggressive bacterial species or globally decrease luminal and mucosal bacterial concentrations, depending on their spectrum of activity. Alternatively, administration of beneficial bacterial species (probiotics), poorly absorbed dietary oligosaccharides (prebiotics), or combined probiotics and prebiotics (synbiotics) can restore a predominance of beneficial commensal flora. These two therapeutic approaches are not, of course, mutually exclusive. Rifaximin, a poorly absorbed antibiotic targeted at the gastrointestinal tract, has been long used in Italy for the treatment of infectious diarrhea in both adults and children. During the past few years the appreciation of the pathogenic role of gut bacteria in several organic and functional gastrointestinal diseases has increasingly broadened its clinical use, which now covers hepatic encephalopathy, small intestine bacterial overgrowth, inflammatory bowel disease and colonic diverticular disease. Other potential clinical indications are being explored and look promising. 

Table of contents:

1. Foreword

2. Preface

3. Enteric Flora in Health and Disease

4. Experimental and Clinical Pharmacology of Rifaximin a Gastrointestinal Selective Antibiotic

5. Pharmacological Treatment of the Irritable Bowel Syndrome and Other Functional Bowel Disorders

6. Is There Room for Antibiotics?

7. Pathophysiology and Clinical Picture

8. Management of Colonic Diverticular Disease

9. Current Therapeutic Options

10. Antimicrobials in the Management of Inflammatory Bowel Disease

11. From Pathophysiology to Treatment

12. Focus on Antibiotic Therapy

13. Epidemiology Etiology and Pathophysiology of Travelers Diarrhea

14. Prevention and Treatment of Travelers Diarrhea

15. Treatment Options

16. Are RifaximinBased Regimens Effective?

17. A Role for Antibiotics?

18. Author Index

19. Subject Index

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Tags: C Scarpignato, A Lanas, Bacterial, Flora, Digestive, Disease, Rifaximin