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ISBN 10: 0748772103
ISBN 13: 978-0748772100
Author: Nessar Ahmed, Maureen Dawson, Chris Smith, Ed Wood
Biology of Disease describes the biology of many of the human disorders and disease that are encountered in a clinical setting. It is designed for first and second year students in biomedical science programs and will also be a highly effective reference for health science professionals as well as being valuable to students beginning medical school. Real cases are used to illustrate the importance of biology in understanding the causes of diseases, as well as in diagnosis and therapy.
CHAPTER 1: THE NATURE AND INVESTIGATION OF DISEASES
1.1 INTRODUCTION
1.2 CHARACTERISTIC FEATURES OF DISEASES
1.3 CLASSIFICATION OF DISEASES
1.4 EPIDEMIOLOGY OF DISEASE
1.5 INVESTIGATING DISEASES
1.6 TYPES OF PATHOLOGY LABORATORIES
1.7 ROLE OF HOSPITAL LABORATORY TESTS
1.8 HOSPITAL LABORATORY TESTS
1.9 EVALUATION OF LABORATORY TESTS
1.10 REFERENCE RANGES
1.11 QUALITY OF TEST RESULTS AND CLINICAL AUDITING
1.12 SUMMARY
FURTHER READING
CHAPTER 2: PATHOGENS AND VIRULENCE
2.1 INTRODUCTION
2.2 TYPES OF PATHOGENS
2.3 VIRULENCE FACTORS
2.4 COURSE OF INFECTION
2.5 SUMMARY
FURTHER READING
CHAPTER 3: INFECTIOUS DISEASES AND TREATMENTS
3.1 INTRODUCTION
3.2 INFECTIONS OF THE SKIN
3.3 INFECTIONS OF THE EYES, EARS AND CENTRAL NERVOUS SYSTEM
3.4 INFECTIONS OF THE RESPIRATORY SYSTEM
3.5 INFECTIONS OF THE GASTROINTESTINAL TRACT
3.6 INFECTIONS OF THE UROGENITAL SYSTEM
3.7 SEPSIS AND SYSTEMIC INFECTIONS
3.8 INVESTIGATING INFECTIOUS DISEASES
3.9 PREVENTING INFECTIOUS DISEASES
3.10 CONTROLLING THE SPREAD OF PATHOGENS
3.11 TREATMENT OF INFECTIOUS DISEASES
3.12 SUMMARY
FURTHER READING
CHAPTER 4 THE IMMUNE SYSTEM
4.1 INTRODUCTION
4.2 TYPES OF IMMUNE DEFENSE
4.3 NONSPECIFIC DEFENSES
4.4 SPECIFIC IMMUNE RESPONSES
4.5 SMALL LYMPHOCYTES
4.6 PRODUCTION OF A SPECIFIC IMMUNE RESPONSE
4.7 SUMMARY
FURTHER READING
CHAPTER 5: DISORDERS OF THE IMMUNE SYSTEM
5.1 INTRODUCTION
5.2 IMMUNODEFICIENCY DISEASES
5.3 AUTOIMMUNE DISORDERS
5.4 IMMUNOLOGICAL HYPERSENSITIVITY
5.5 SUMMARY
FURTHER READING
CHAPTER 6: TRANSFUSION AND TRANSPLANTATION
6.1 INTRODUCTION
6.2 BLOOD AND BLOOD PRODUCTS FOR TRANSFUSION
6.3 THE DISCOVERY OF THE BLOOD GROUP SYSTEMS
6.4 THE ABO BLOOD GROUP SYSTEM (ISBT 001)
6.5 THE RH BLOOD GROUP SYSTEM (ISBT 004)
6.6 OTHER BLOOD GROUP SYSTEMS
6.7 LABORATORY DETERMINATION OF BLOOD GROUPS
6.8 ROLE OF COMPLEMENT IN TRANSFUSION REACTIONS
6.9 HAZARDS OF TRANSFUSION
6.10 SCREENING OF BLOOD DONORS
6.11 TRANSPLANTATION OF SOLID TISSUES AND ORGANS
6.12 THE HLA SYSTEM
6.13 IMMUNOSUPPRESSION
6.14 HEMOPOIETIC STEM CELL TRANSPLANTATION
6.15 SUMMARY
FURTHER READING
CHAPTER 7: DISORDERS OF THE ENDOCRINE SYSTEM
7.1 INTRODUCTION
7.2 HORMONE PRODUCTION
7.3 MECHANISMS OF HORMONAL ACTION
7.4 CAUSES OF ENDOCRINE DISORDERS
7.5 THE PITUITARY GLAND
7.6 GROWTH HORMONE DISORDERS
7.7 THYROID HORMONE DISORDERS
7.8 REGULATION OF BLOOD GLUCOSE
7.9 DISORDERS OF THE ADRENAL CORTEX
7.10 REPRODUCTIVE HORMONES
7.11 SUMMARY
FURTHER READING
CHAPTER 8: DISORDERS OF WATER, ELECTROLYTES AND URATE BALANCES
8.1 INTRODUCTION
8.2 KIDNEYS
8.3 DISORDERS OF WATER HOMEOSTASIS
8.4 DISORDERS OF Na+ HOMEOSTASIS
8.5 DISORDERS OF K+ HOMEOSTASIS
8.6 DISORDERS OF Ca2+ HOMEOSTASIS
8.7 DISORDERS OF PHOSPHATE HOMEOSTASIS
8.8 DISORDERS OF Mg2+ HOMEOSTASIS
8.9 DISORDERS OF URATE METABOLISM
8.10 SUMMARY
FURTHER READING
CHAPTER 9: DISORDERS OF ACID–BASE BALANCE
9.1 INTRODUCTION
9.2 THE PRODUCTION AND TRANSPORT OF CARBON DIOXIDE
9.3 BUFFERING AND THE EXCRETION OF H+
9.4 TYPES OF ACID–BASE DISORDERS
9.5 INVESTIGATING ACID–BASE DISORDERS
9.6 SUMMARY
FURTHER READING
CHAPTER 10: DIET AND DISEASE
10.1 INTRODUCTION
10.2 DIET AND NUTRITION
10.3 NUTRITIONAL DISORDERS
10.4 INVESTIGATING NUTRITIONAL DISORDERS
10.5 GENERAL MANAGEMENT OF NUTRITIONAL DISORDERS
10.6 SUMMARY
FURTHER READING
CHAPTER 11: DISORDERS OF THE GASTROINTESTINAL TRACT, PANCREAS, LIVER AND GALL BLADDER
11.1 INTRODUCTION
11.2 THE GASTROINTESTINAL TRACT AND ITS ACCESSORY ORGANS
11.3 DIGESTION
11.4 ABSORPTION OF THE PRODUCTS OF DIGESTION
11.5 ACTIVITIES OF THE LARGE INTESTINE
11.6 THE SMALL INTESTINE AND HOMEOSTASIS
11.7 HORMONAL CONTROL OF GIT SECRETIONS
11.8 DISORDERS OF THE GIT AND ACCESSORY ORGANS
11.9 SUMMARY
FURTHER READING
CHAPTER 12: TOXICOLOGY
12.1 INTRODUCTION
12.2 DRUG ACTION, METABOLISM, DISTRIBUTION AND EXCRETION
12.3 PHYSIOLOGICAL DETOXIFICATION MECHANISMS
12.4 SYMPTOMATIC POISONING
12.5 COMMON POISONS
12.6 SUMMARY
FURTHER READING
CHAPTER 13: DISORDERS OF THE BLOOD
13.1 INTRODUCTION
13.2 BLOOD CELLS AND PLATELETS
13.3 HEMOGLOBINS
13.4 HEMOSTASIS AND BLOOD CLOTTING
13.5 ANEMIAS
13.6 HEMOGLOBINOPATHIES
13.7 GLUCOSE 6-PHOSPHATE DEHYDROGENASE DEFICIENCY (G6PD)
13.8 CLINICAL ASPECTS OF CLOTTING
13.9 THROMBOCYTOPENIA AND THROMBOCYTOSIS
13.10 SUMMARY
FURTHER READING
CHAPTER 14: DISORDERS OF THE CARDIOVASCULAR SYSTEM
14.1 INTRODUCTION
14.2 THE HEART AND CIRCULATORY SYSTEMS
14.3 BLOOD VESSELS
14.4 BLOOD PRESSURE
14.5 INVESTIGATING CARDIAC FUNCTION IN HEALTH AND DISEASE
14.6 ENDOCARDITIS
14.7 ABNORMAL HEART RHYTHMS
14.8 CARDIAC FAILURE
14.9 ISCHEMIC HEART DISEASE
14.10 CARDIOMYOPATHIES
14.11 HEART VALVE DISORDERS
14.12 HEART TUMORS
14.13 ATHEROSCLEROSIS OR ARTERIOSCLEROSIS
14.14 MYOCARDIAL INFARCTION
14.15 PERICARDIAL DISEASES
14.16 DISORDERS OF ARTERIES AND VEINS
14.17 CLINICAL PROBLEMS ASSOCIATED WITH BLOOD PRESSURE
14.18 SUMMARY
FURTHER READING
CHAPTER 15: GENETIC DISEASES
15.1 INTRODUCTION
15.2 GENETICS AND DNA
15.3 DNA REPLICATION AND THE CELL CYCLE
15.4 GENOTYPE AND PHENOTYPE
15.5 INHERITANCE AND MUTATIONS
15.6 INHERITED GENE DISORDERS
15.7 CHROMOSOMES AND THE HUMAN KARYOTYPE
15.8 CHROMOSOMAL MUTATIONS OR ABERRATIONS
15.9 VARIATIONS IN CHROMOSOME NUMBERS
15.10 DETECTING, DIAGNOSING AND SCREENING HUMAN GENETIC DISEASES
15.11 SUMMARY
FURTHER READING
CHAPTER 16: MEMBRANE, ORGANELLE AND CYTOSKELETAL DISORDERS
16.1 INTRODUCTION
16.2 NUCLEUS AND NUCLEOCYTOPLASMIC TRANSPORT
16.3 PLASMA MEMBRANE DISORDERS
16.4 MITOCHONDRIAL DISORDERS
16.5 PEROXISOMAL DISORDERS
16.6 LYSOSOMAL DISORDERS
16.7 CYTOSKELETAL DISORDERS
16.8 SUMMARY
FURTHER READING
CHAPTER 17: CANCER
17.1 INTRODUCTION
17.2 CLASSIFICATION OF CANCER TYPES
17.3 EPIDEMIOLOGY OF CANCER
17.4 MOLECULAR BIOLOGY OF CANCER
17.5 CAUSES OF CANCER
17.6 GENERAL DIAGNOSIS OF CANCER
17.7 GENERAL TREATMENT OF CANCER
17.8 SPECIFIC TYPES OF CANCERS
17.9 SUMMARY
FURTHER READING
CHAPTER 18: AGING AND DISEASE
18.1 INTRODUCTION
18.2 AGING OF CELLS, TISSUES, ORGANS AND SYSTEMS
18.3 CAUSES OF AGING
18.4 AGE-RELATED DISEASES
18.5 CALORIE RESTRICTION AND AGING
18.6 INVESTIGATIONS AND MANAGEMENT OF THE ELDERLY
18.7 SUMMARY
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Tags: Nessar Ahmed, Maureen Dawson, Chris Smith, Ed Wood, Biology of Disease
