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0 reviewsBACKGROUND Alcohol consumption is a known contributor to elevated blood pressure (BP). However, the association between changes in light-to-moderate alcohol consumption (eg, #1 drink for women and #2 drinks for men daily),especially cessation, and BP remains unclear.OBJECTIVE In this study, the authors sought to evaluate the associations between alcohol cessation/initiation andsubsequent BP changes, focusing on sex-specific estimates, light-to-moderate intake, and type of alcoholic beverage.METHODS We analyzed data from adults undergoing annual health checkups at a Japanese preventive medicine centerfrom October 2012 to March 2024. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes betweenconsecutive visits were evaluated. Alcohol intake was self-reported as standard drinks (1 drink = 10 g ethanol). Associations between alcohol cessation/initiation and BP changes were assessed with the use of generalized estimatingequations, adjusted for demographics, clinical history, and lifestyle behaviors.RESULTS Among 359,717 visits from 58,943 participants, the cessation cohort (53,156 visits, 25,621 participants,median age 50.5 years, 52.1% women) revealed that cessation was associated with dose-dependent reductions in BP.Among women, cessation of 0.5 to 1.0 drinks per day did not correspond to a statistically significant change in SBP(− 0.44 mm Hg; 95% CI: − 0.93 to 0.06 mm Hg) and corresponded to a change of − 0.41 mm Hg (95% CI: − 0.77to − 0.05 mm Hg) in DBP, and cessation of 1.0 to 2.0 drinks per day corresponded to changes of − 0.78 mm Hg(95% CI: − 1.53 to − 0.04 mm Hg) in SBP and − 1.14 mm Hg (95% CI: − 1.68 to − 0.61 mm Hg) in DBP. Among men,cessation of 0.5 to 1.0 drinks per day did not correspond to a statistically significant change in SBP (− 0.27 mm Hg;95% CI: − 0.81 to 0.27 mm Hg) or DBP (− 0.39 mm Hg; 95% CI: − 0.77 to 0.01 mm Hg), and cessation o
