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ISBN 10: 0824754158
ISBN 13: 9780824754150
Author: George Coukos, Stephen C Rubin
The only guide to provide comprehensive coverage of the management of endometrial cancer, as well as cancers in, on, and around the uterus. Studies the impact of diagnostic tools, imaging techniques, and sampling procedures in the evaluation and management of various cancers. Discusses late and advanced stage treatments including radiation and surgery.
1. Molecular Genetics of Uterine Malignancies
Introduction
Genetic And Environmental Factors
Inherited Risk
Sporadic Cancers: Acquired Genetic Changes
DNA Mismatch Repair Defects
Tumor Suppressor Gene Defects
Oncogenes
Summary
References
2. Endometrial Cancer in the Hereditary Nonpolyposis Colorectal Cancer Syndrome
Introduction
Clinical And Pathologic Features Of Hnpcc-Related Cancers
Endometrial Cancer
Ovarian Cancer
Colorectal Cancer
Other Malignancies
Genetic Basis Of Hnpcc
Identifying The Hnpcc Syndrome
Clinical Diagnosis
Genetic Testing
Testing Recommendations and Interpretation of Results
Counseling Regarding Screening And Prevention
Screening for Gynecologic Cancers (Table 2)
Screening for Colorectal Cancer (Table 2)
Screening for Other Cancers (Table 2)
Lifestyle
Chemoprevention
Prophylactic Surgery
Gynecologic Cancer
Colorectal Cancer
Conclusion
References
3. Steroid Hormone Receptors in the Normal Endometrium and in Endometrial Cancer
Introduction: Endometrial Cancer And The Link To Steroid Hormones And Steroid Receptors
Hormone Receptors In The Normal Endometrium
Hormonal Effects And Hormone Receptors In Endometrial Cancer
Ligand Binding Assays And Immunohistochemistry To Determine Steroid Receptor Status
Cross-Talk And Expression In Endometrial Glands And Stroma
Genomic Effects Of Srs
Receptor Isoforms
Non-Genomic Effects Of Steroid Hormones Through Membrane And Cytosolic Receptors
References
4. The Effects of Tamoxifen on the Endometrium
Introduction
Endometrial Carcinoma
Histology Of Tamoxifen-Associated Uterine Cancer
The Role Of Screening
References
5. Pathology of Endometrial Hyperplasia and Carcinoma
Classification
Precursors Of Endometrial Carcinoma
Precursors of Type I Carcinomas
Precursors of Type II Carcinomas
Endometrioid Carcinoma
Gross Findings
Microscopic Findings
Differential Diagnosis
Prognostic Factors
Patterns of Spread
Variants of Endometrioid Carcinoma
Villoglandular Adenocarcinoma
Endometrioid Carcinoma with Squamous Differentiation
Gross and Microscopic Findings
Differential Diagnosis
Behavior
Mucinous Carcinoma
Serous Carcinoma
Gross Findings
Microscopic Findings
Differential Diagnosis
Behavior
Clear Cell Carcinoma
Mixed Types Of Carcinoma
Malignant Mesodermal Mixed Tumor (Mmmt)/Carci Nosarcoma
Undifferentiated Carcinoma
Molecular Genetics Of Endometrial Cancer
Endometrioid Carcinoma
Serous Carcinoma
References
6. Pathology of Uterine Sarcomas
Classification Of Uterine Mesenchymal, And Mixed Mesenchymal/Epithelial Neoplasms
Endometrial Stromal Sarcoma (Ess) (1-3)
Clinical Features
Gross Pathology
Microscopic Pathology (Figs. 1 and 2)
Clinicopathologic Correlation
Managerially Relevant Differential Diagnostic Issues
Clinical Disease I (Benign) Conditions with which ESS May Be Confused
Clinical Disease II Conditions with which ESS May Be Confused
Other Clinical Disease II Conditions with which ESS May Be Confused
Clinical Disease IV Conditions with which ESS May Be Confused
Uterine Neoplasms With Sex Cord-Like Elements (26,29,30,41-43)
Leiomyosarcoma (1,3)
cancer of the uterus
what causes cancer of the uterus
cancer uterus quel age
cancer of the uterus survival rate
cancer of the uterus risk factors
what does cancer on the uterus look like
where is uterine cancer located
Tags: George Coukos, Stephen C Rubin, Cancer, Uterus
