Cell Invasion Medical Intelligence Unit 1st Edition by Jyrki Heino, Veli Matti Kahari ISBN 1587060736 9781587060731 by Jyrki Heino, Veli-matti Kahari, 1587060736, 9781587060731 instant download after payment.

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ISBN 10: 1587060736 
ISBN 13: 9781587060731
Author: Jyrki Heino, Veli Matti Kahari

Cell Invasion Medical Intelligence Unit 1st Table of contents:

Introduction

• 1. An Overview of Cell Invasion
  • A. Definition and Significance of Cell Invasion
  • B. The Extracellular Matrix (ECM) as a Barrier
  • C. Key Cellular Components and Molecular Players

Part I: The Molecular Machinery of Invasion

• Chapter 1: Matrix Metalloproteinases (MMPs) in Cancer Cell Invasion

  • 1.1 The MMP Family and Their Role in ECM Degradation
  • 1.2 Regulation of MMP Activity and Expression
  • 1.3 MMPs as Therapeutic Targets in Cancer

• Chapter 2: The Role of Integrins in Cell-Extracellular Matrix Interactions

  • 2.1 Structure and Function of Integrin Receptors
  • 2.2 Integrin Signaling and its Regulation of Cell Adhesion and Migration
  • 2.3 Specific Integrins in Cancer Invasion and Wound Healing

• Chapter 3: The Plasminogen Activation System in Cell Invasion

  • 3.1 Components of the Plasminogen Activation System (uPA, tPA, PAI-1)
  • 3.2 The Role of Plasmin in Proteolysis and Cell Migration
  • 3.3 The uPA/uPAR System in Cancer and Other Diseases

• Chapter 4: Emmprin (CD147), a Tumor Cell Surface Inducer of Matrix Metalloproteinase Production

  • 4.1 Emmprin's Structure and Location
  • 4.2 How Emmprin Induces MMPs and Promotes Invasion
  • 4.3 Emmprin as a Potential Target for Anti-Invasive Therapies

Part II: Mechanistic Features and Specific Biological Contexts

• Chapter 5: Common Mechanistic Features in Cell-Extracellular Matrix Interactions

  • 5.1 Adhesion, Proteolysis, and Motility: A Coordinated Process
  • 5.2 The Role of the Cytoskeleton in Cell Protrusion and Movement
  • 5.3 Signal Transduction Pathways Regulating Invasion

• Chapter 6: Keratinocyte Interactions with Fibronectin During Wound Healing

  • 6.1 The Process of Re-epithelialization in Wound Healing
  • 6.2 The Importance of Fibronectin as a Substrate for Keratinocyte Migration
  • 6.3 Signaling Pathways Governing Keratinocyte Behavior During Repair

• Chapter 7: Matrix Metalloproteinases and Cell Migration in the Development of Cardiovascular Disease

  • 7.1 MMPs in Vascular Remodeling and Atherosclerosis
  • 7.2 The Role of Cell Migration in Angiogenesis and Plaque Formation
  • 7.3 Therapeutic Implications of Targeting MMPs in Cardiovascular Disease

• Chapter 8: Cancer Invasion-Related Genes

  • 8.1 Overview of Genes Involved in the Invasion-Metastasis Cascade
  • 8.2 Genetic and Epigenetic Regulation of Invasion
  • 8.3 The Role of Tumor Suppressor Genes and Oncogenes in Invasion

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Tags: Jyrki Heino, Veli Matti Kahari, Invasion, Intelligence