Cold Memories Control Wholebody Thermoregulatory Responses Andrea Muampx000f1oz Zamora Aaron Douglas Paul B Conway Esteban Urrieta Taylor Moniz James D Oampx02019leary Lydia Marks Christine A Denny Clara Ortegade San Luis Lydia Lynch Tomampx000e1s J Ryan by Andrea Muamp#x000f1;oz Zamora & Aaron Douglas & Paul B. Conway & Esteban Urrieta & Taylor Moniz & James D. Oamp#x02019;leary & Lydia Marks & Christine A. Denny & Clara Ortega-de San Luis & Lydia Lynch & Tomamp#x000e1;s J. Ryan instant download after payment.

Environmental thermal challenges trigger the brain to coordinate both autonomic Open accessand behavioural responses to maintain optimal body temperature1–4. It is unknown Check for updateshow temperature information is precisely stored and retrieved in the brain and how it is converted into a physiological response. Here we investigated whether memories could control whole-body metabolism by training mice to remember a thermal challenge. Mice were conditioned to associate a context with a specifc temperature by combining thermoregulatory Pavlovian conditioning with engram-labelling technology, optogenetics and chemogenetics. We report that if mice are returned to an environment in which they previously experienced a 4 °C cold challenge, they increase their metabolic rates regardless of the actual environmental temperature. Furthermore, we show that mice have increased hypothalamic activity when they are exposed to the cold, and that a specifc network emerges between the hippocampus and the hypothalamus during the recall of a cold memory. Both natural retrieval and artifcial reactivation of cold-sensitive memory engrams in the hippocampus mimic the physiological responses that are seen during a cold challenge. These ensembles are necessary for cold-memory retrieval. These fndings show that retrieval of a cold memory causes whole-body autonomic and behavioural responses that enable mice to maintain thermal homeostasis.