Continued Enteral Nutrition Until Extubation Compared With Fasting Before Extubation In Patients In The Intensive Care Unit An Openlabel Clusterrandomised Parallelgroup Noninferiority Trial Mickaãl Landais Md Maianh Nay Md Johann Auchabie Md Noemie Hubert Md Aurãlien Frerou Md Aihem Yehia Md Prof Alain Mercat Phd Maud Jonas Md Frãdãric Martino Md Mikael Moriconi Md Anne Courte Md Vincent Robertedan Md by Mickaël Landais Md & Mai-anh Nay Md & Johann Auchabie Md & Noemie Hubert Md & Aurélien Frerou Md & Aihem Yehia Md & Prof Alain Mercat Phd & Maud Jonas Md & Frédéric Martino Md & Mikael Moriconi Md & Anne Courte Md & Vincent Robert-edan Md &… instant download after payment.

Summary Background Fasting is frequently imposed before extubation in patients in intensive care units, with the aim to reduce Lancet Respir Med 2023; 11: 319–28risk of aspiration. This unevaluated practice might delay extubation, increase workload, and reduce caloric intake. We aimed to compare continued enteral nutrition until extubation with fasting before extubation in patients in the Published OnlineJanuary 21, 2023intensive care unit. We conducted an open-label, cluster-randomised, parallel-group, non-inferiority trial in 22 intensive care S2213-2600(22)00413-1See Comment page 298units in France. Patients aged 18 years or older were eligible for enrolment if they had received invasive mechanical For the Chinese translation of the ventilation for at least 48 h in the intensive care unit and received prepyloric enteral nutrition for at least 24 h at the abstract see Online for time of extubation decision. Centres were randomly assigned (1:1) to continued enteral nutrition until extubation or appendix 16-h fasting with concomitant gastric suctioning before extubation, to be applied for all patients within the unit. *Contributed equallyMasking was not possible because of the nature of the trial. The primary outcome was extubation failure (composite †Contributors are listed in criteria of reintubation or death) within 7 days after extubation, assessed in both the intention-to-treat and per-protocol appendix 2 (pp 3–4)populations. The non-inferiority margin was set at 10%. Pneumonia within 14 days of extubation was a key secondary Réanimation Polyvalente, Centre Hospitalier du Mans, endpoint. This trial is now complete and is registered with ClinicalTrials.gov, NCT03335345.Le Mans, France (M Landais MD, Findings Between April 1, 2018, and Oct 31, 2019, 7056 patients receiving enteral nutrition and mechanical ventilation N Chudeau MD, A Robert PhD); Médecine Intensive were admitted to the in