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Coronaviruses and their Diseases 1st Edition by David Cavanagh, T David K Brown ISBN 9781468458251

SKU: BELL-216856000

$ 31.00 ~~$ 45.00~~ (-31%)

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Coronaviruses and their Diseases 1st Edition by David Cavanagh, T David K Brown ISBN 9781468458251 instant download after payment.

Publisher: Springer

File Extension: PDF

File size: 72.93 MB

Author: David Cavanagh & T. David K. Brown

Language: English

Year: 2012

Product desciption

Coronaviruses and their Diseases 1st Edition by David Cavanagh, T David K Brown ISBN 9781468458251 by David Cavanagh & T. David K. Brown instant download after payment.

Coronaviruses and their Diseases 1st Edition by David Cavanagh, T David K Brown - Ebook PDF Instant Download/Delivery: 9781468458251
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ISBN 13: 9781468458251
Author: David Cavanagh, T David K Brown

Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.

Coronaviruses and their Diseases 1st Table of contents:

Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes
Functions of Coronavirus Glycoproteins
Biosynthesis and Function of the Coronavirus Spike Protein
Functional Analysis of the Coronavirus MHV-JHM Surface Glycoproteins
Role of pH in Syncytium Induction and Genome Uncoating
Is the 110K Glycoprotein the Only Receptor for MHV?
MHV-Resistant SJL/J Mice and Non-Functional MHV Receptor
Fc Receptor-Like Activity of MHV E2 Glycoprotein
Mouse Fibroblast Mutants and Resistance to MHV
Membrane Cytopathology of MHV Infection
Molecular Characterization of Human Coronavirus 229E
Sequence Analysis of BECV Genome
Coronavirus M and HE Glycoproteins
Structure and Expression of Bovine Coronavirus HE Protein
Similarity of Bovine Coronavirus and Influenza C Virus HA
Acetylesterase of Hemagglutinating Encephalomyelitis Virus
Reactivity of BCV and Influenza C with NEU5,9AC2 Receptors

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Tags: David Cavanagh, T David K Brown, Coronaviruses, Diseases

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Coronaviruses and their Diseases 1st Edition by David Cavanagh, T David K Brown ISBN 9781468458251