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Current Concepts in Autoimmunity and Chronic Inflammation Current Topics in Microbiology and Immunology 2006th Edition by Andreas Radbruch, Peter E Lipsky ISBN 3540297138‎ 978-3540297130

  • SKU: BELL-2003218
Current Concepts in Autoimmunity and Chronic Inflammation Current Topics in Microbiology and Immunology 2006th Edition by Andreas Radbruch, Peter E Lipsky ISBN 3540297138‎ 978-3540297130
$ 31.00 $ 45.00 (-31%)

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Current Concepts in Autoimmunity and Chronic Inflammation Current Topics in Microbiology and Immunology 2006th Edition by Andreas Radbruch, Peter E Lipsky ISBN 3540297138‎ 978-3540297130 instant download after payment.

Publisher: Springer
File Extension: PDF
File size: 4.69 MB
Pages: 292
Author: A. Radbruch, P.E. Lipsky
ISBN: 9783540297130, 9783540297147, 3540297138, 3540297146
Language: English
Year: 2006
Edition: 1

Product desciption

Current Concepts in Autoimmunity and Chronic Inflammation Current Topics in Microbiology and Immunology 2006th Edition by Andreas Radbruch, Peter E Lipsky ISBN 3540297138‎ 978-3540297130 by A. Radbruch, P.e. Lipsky 9783540297130, 9783540297147, 3540297138, 3540297146 instant download after payment.

Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology) 2006th Edition by Andreas Radbruch, Peter E. Lipsky - Ebook PDF Instant Download/Delivery: 3540297138,‎ 978-3540297130

Full download Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology) 2006th Edition after payment

 

 

Product details:

ISBN 10: 3540297138‎

ISBN 13: 978-3540297130 

Author: Andreas Radbruch, Peter E. Lipsky

The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.

Table of contents:

  1. Front matter

  2. B cell tolerance—how to make it and how to break it

  3. Breaking ignorance: the case of the brain

  4. Naturally arising Foxp3-expressing CD25⁺CD4⁺ regulatory T cells in self-tolerance and autoimmune disease

  5. Sex hormones and SLE: influencing the fate of autoreactive B cells

  6. Innate (over)immunity and adaptive autoimmune disease

  7. Can unresolved infection precipitate autoimmune disease?

  8. The systemic autoinflammatory diseases: inborn errors of the innate immune system

  9. Inefficient clearance of dying cells and autoreactivity

  10. The importance of T cell interactions with macrophages in rheumatoid cytokine production

  11. T cell activation as starter and motor of rheumatic inflammation

  12. Signalling pathways in B cells: implications for autoimmunity

  13. Immunological memory stabilizing autoreactivity

  14. Genetics of autoimmune diseases: a multistep process

  15. Back matter

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Tags: Andreas Radbruch, Peter E Lipsky, Current, Concepts, Autoimmunity, Chronic, Inflammation, Microbiology, Immunology

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