Cytochrome P450 2d6 Shufeng Zhou by Shufeng Zhou 9781466597877, 1466597879 instant download after payment.

Cytochromes are proteinsthat
catalyze electron transfer reactions of well-known metabolic pathways
and are classified in various superfamilies. The CYP, or P450,
superfamily accounts for 90% of the oxidative metabolism of clinical
drugs. One member of this superfamily, P450 2D6 (or CYP2D6),
singlehandedly metabolizes about 25% of all medications in the human
liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism
reviews the current knowledge of CYP2D6 as well as the maturing body of
evidence indicating its significance to clinical and pharmacological
researchers and practitioners.

This book focuses on the critical
role CYP2D6 plays in the human liver. It examines the genetic,
epigenetic, physiological, pathological, and structural factors of the
gene that govern the highly variable metabolism of a number of drugs in
clinical use. It highlights the impact of the functional roles of CYP2D6
on clinical practice and drug development and also discusses
implications for precise medicine, strategies to avoid adverse drug
reactions, and paths for future research.

Cytochrome P450 2D6 is
a unique, valuable book focusing on a single but immensely powerful
human gene. It provides the first single source of comprehensive
information on CYP2D6 that serves as an important reference for medical,
biomedical, pharmaceutical, and nursing researchers, practitioners, and
students.

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