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Dna Damage Controlling Systems In Mitochondria 1st Edition Dr Kanchanjunga Prasai

Name: Dna Damage Controlling Systems In Mitochondria 1st Edition Dr Kanchanjunga Prasai
SKU: BELL-46116748
Price: 31.00 USD
Availability: InStock
Rating: 4.1 (80 reviews)

SKU: BELL-46116748

$ 31.00 ~~$ 45.00~~ (-31%)

4.1

80 reviews

Dna Damage Controlling Systems In Mitochondria 1st Edition Dr Kanchanjunga Prasai instant download after payment.

Publisher: Nai Prakashan

File Extension: PDF

File size: 4.61 MB

Pages: 155

Author: Dr. Kanchanjunga Prasai

ISBN: 9789937509947, 9789771477143, 9771477145, 9937509947

Language: English

Year: 2021

Edition: 1

Product desciption

Dna Damage Controlling Systems In Mitochondria 1st Edition Dr Kanchanjunga Prasai by Dr. Kanchanjunga Prasai 9789937509947, 9789771477143, 9771477145, 9937509947 instant download after payment.

Mitochondria are essential double membrane organelles
within a cell that harbor their own genetic material, the
mitochondrial DNA (mtDNA), which encodes indispensable
protein components of the electron transport chain (ETC) and
oxidative phosphorylation (OXPHOS). Apart from generating the
majority of the cell’s adenosine triphosphate (ATP) that drives a
multitude of reactions necessary for life, the OXPHOS machinery
is also the primary source of reactive oxygen species (ROS). Since
mtDNA is located in close proximity to the ROS generating factory
and is also not protected as complex nucleosomes like the nuclear
counterpart, mtDNA is under constant threat not only from ROS
but also from environmental factors like ionizing radiation. These
endogenous and exogenous agents have the potential to damage
mtDNA molecules, which can result in the loss of mtDNA integrity.
As mtDNA encodes protein components of the ETC and OXPHOS,
failure to tackle mtDNA lesions can lead to disruption of the ETC
and enhanced ROS production, which can, in turn, result in energy
depletion, cell death, organ dysfunction, and ultimately disease.
Therefore, maintaining the stability of mtDNA is critical not only
for mitochondrial and cellular function but also for organismal
fitness. This book focuses on our current knowledge of different
mtDNA repair mechanisms that help preserve the integrity ofthe mitochondrial genome. Our current comprehension of the
degradation of damaged mtDNA molecules and molecular players
involved in the process are discussed. Finally, the roles of sanitation
of premutagenic free nucleotides in mitigating mtDNA damage and
translesion synthesis as an important strategy in tolerating damage
to the mitochondrial genome are also summarized.