DNA Repair and Human Disease 1st Edition by Adayabalam Balajee ISBN 0387341951 9780387341958 by Adayabalam Balajee 0387341951 instant download after payment.

DNA Repair and Human Disease 1st Edition by Adayabalam Balajee - Ebook PDF Instant Download/Delivery: 0387341951, 9780387341958
Full download DNA Repair and Human Disease 1st Edition after payment

Product details:

ISBN 10: 0387341951 
ISBN 13: 9780387341958
Author: Adayabalam Balajee

DNA Repair and Human Disease 1st Table of contents:

Part I: Fundamentals of DNA Damage and Repair

1. Introduction to DNA Damage
   • Sources of DNA Damage (Endogenous and Exogenous)
   • Types of DNA Damage (Oxidative, Alkylation, Deamination, UV-induced, Strand Breaks)
   • Consequences of Unrepaired DNA Damage
2. Basic Mechanisms of DNA Repair
   • Direct Reversal:
     • Photoreactivation
     • Alkyltransferase (e.g., MGMT)
   • Base Excision Repair (BER):
     • Mechanism, Key Enzymes (DNA Glycosylases, AP Endonuclease, DNA Polymerase β, Ligase)
     • Repair of Oxidative and Alkylating Damage
   • Nucleotide Excision Repair (NER):
     • Global Genomic Repair (GGR)
     • Transcription-Coupled Repair (TCR)
     • Mechanism, Key Protein Complexes (XP proteins, TFIIH)
   • Mismatch Repair (MMR):
     • Mechanism, Key Proteins (MutS, MutL homologs)
     • Repair of Replication Errors
   • Double-Strand Break (DSB) Repair:
     • Non-Homologous End Joining (NHEJ)
     • Homologous Recombination (HR)
     • Alternative End Joining (A-EJ)
   • Translesion Synthesis (TLS) and DNA Damage Tolerance
   • Interstrand Crosslink (ICL) Repair
   • Ubiquitination and Sumoylation in DNA Repair

Part II: DNA Repair Defects and Human Disease Syndromes

3. DNA Repair and Cancer
   • Genomic Instability as a Hallmark of Cancer
   • Role of DNA Repair Gene Mutations in Cancer Predisposition
   • Specific Cancers Linked to DNA Repair Defects (e.g., Breast/Ovarian Cancer - BRCA1/2, Lynch Syndrome - MMR, Xeroderma Pigmentosum - NER)
   • Therapeutic Implications: Synthetic Lethality (e.g., PARP Inhibitors)
4. Neurodegeneration and DNA Repair
   • Role of DNA Damage in Neuronal Health and Disease
   • Ataxia-Telangiectasia (AT) and ATM pathway
   • Ataxia with Oculomotor Apraxia (AOA)
   • Cockayne Syndrome (CS) and Transcription-Coupled Repair
   • Huntington's Disease, Alzheimer's Disease, Parkinson's Disease (connections to DNA repair)
5. Premature Aging Syndromes
   • Werner Syndrome
   • Bloom Syndrome
   • Hutchinson-Gilford Progeria Syndrome
   • Connections to DNA Damage Accumulation and Repair Dysfunction
6. Immunodeficiency Syndromes
   • SCID (Severe Combined Immunodeficiency) and V(D)J Recombination Defects
   • LIG4 Syndrome
   • DNA Ligase IV, Artemis deficiencies
7. Other Genetic Disorders Linked to DNA Repair
   • Fanconi Anemia (ICL Repair)
   • Trichothiodystrophy (TTD)
   • Cancers associated with specific repair deficiencies (e.g., stomach, colorectal)

Part III: DNA Repair in Pathophysiology and Therapeutic Strategies

8. DNA Repair in Infectious Diseases
   • Host DNA Repair Response to Viral and Bacterial Infections
   • Impact of Pathogens on Host DNA Repair Pathways
9. Pharmacology of DNA Repair Modulation
   • Chemotherapeutic Agents Targeting DNA (and the repair response)
   • Radiotherapy and DNA Damage
   • DNA Repair Inhibitors (e.g., PARP inhibitors, ATR/ATM inhibitors)
   • Strategies for Sensitizing Cancer Cells to Therapy
10. Biomarkers of DNA Damage and Repair
    • Assays for DNA Damage
    • Assays for DNA Repair Capacity
    • Clinical Applications of Biomarkers in Diagnosis, Prognosis, and Treatment Response
11. Emerging Technologies and Future Directions
    • CRISPR/Cas9 for Gene Editing in DNA Repair Deficiencies
    • Single-Cell Analysis of DNA Repair
    • Precision Medicine Approaches Based on DNA Repair Status
    • Therapeutic Gene Editing for DNA Repair Disorders

People also search for DNA Repair and Human Disease 1st:

dna repair and disease
    
dna repair jobs
    
dna repair disorders
    
dna repair diseases that are inherited
    
the dna-damage response in human biology and disease

Tags: Adayabalam Balajee, DNA, Human