Drug Delivery Strategies For Poorly Watersoluble Drugs Dennis Douroumis by Dennis Douroumis, Alfred Fahr 9780470711972, 9781118444726, 0470711973, 1118444728 instant download after payment.

Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of
techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies.

Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical
formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues.

Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug
delivery, polymers and biomaterials.

Content:
Chapter 1 Self?Assembled Delivery Vehicles for Poorly Water?Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts (pages 1–35): Sylvio May and Alfred Fahr
Chapter 2 Liposomes as Intravenous Solubilizers for Poorly Water?Soluble Drugs (pages 37–66): Peter van Hoogevest, Mathew Leigh and Alfred Fahr
Chapter 3 Drug Solubilization and Stabilization by Cyclodextrin Drug Carriers (pages 67–101): Thorsteinn Loftsson and Marcus E. Brewster
Chapter 4 Solid Lipid Nanoparticles for Drug Delivery (pages 103–149): Sonja Joseph and Heike Bunjes
Chapter 5 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs (pages 151–197): Naveed Ahmed, C.E. Mora?Huertas, Chiraz Jaafar?Maalej, Hatem Fessi and Abdelhamid Elaissari
Chapter 6 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs (pages 199–223): Dagmar Fischer
Chapter 7 Development of Self?Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Soluble Drugs (pages 225–245): Dimitrios G. Fatouros and Anette Mullertz
Chapter 8 Novel Top?Down Technologies: Effective Production of Ultra?Fine Drug Nanocrystals (pages 247–263): C.M. Keck, S. Kobierski, R. Mauludin and R.H. Muller
Chapter 9 Nanosuspensions with Enhanced Drug Dissolution Rates of Poorly Water?Soluble Drugs (pages 265–286): Dennis Douroumis
Chapter 10 Microemulsions for Drug Solubilization and Delivery (pages 287–323): X.Q. Wang and Q. Zhang
Chapter 11 Hot Melt Extrusion: A Process Overview and Use in Manufacturing Solid Dispersions of Poorly Water?Soluble Drugs (pages 325–358): Shu Li, David S. Jones and Gavin P. Andrews
Chapter 12 Penetration Enhancers, Solvents and the Skin (pages 359–371): Jonathan Hadgraft and Majella E. Lane
Chapter 13 Dendrimers for Enhanced Drug Solubilization (pages 373–409): Narendra K. Jain and Rakesh K. Tekade
Chapter 14 Polymeric Micelles for the Delivery of Poorly Soluble Drugs (pages 411–476): Swati Biswas, Onkar S. Vaze, Sara Movassaghian and Vladimir P. Torchilin
Chapter 15 Nanostructured Silicon?Based Materials as a Drug Delivery System for Water?Insoluble Drugs (pages 477–508): Vesa?Pekka Lehto, Jarno Salonen, Helder Santos and Joakim Riikonen
Chapter 16 Micro? and Nanosizing of Poorly Soluble Drugs by Grinding Techniques (pages 509–550): Stefan Scheler
Chapter 17 Enhanced Solubility of Poorly Soluble Drugs Via Spray Drying (pages 551–585): Cordin Arpargaus, David Rutti and Marco Meuri