Drug Discovery Practices Processes And Perspectives Jie Jack L by Jie Jack L, E. J. Corey 9780470942352, 9781118354483, 0470942355, 1118354486 instant download after payment.

Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design.

Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as:

• Target identification and validation
• Drug metabolism and pharmacokinetics
• Central nervous system drugs
• In vitro and in vivo assays
• Cardiovascular drugs
• Cancer drugs

Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field.

Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Content:
Chapter 1 History of Drug Discovery (pages 1–42): Jie Jack Li
Chapter 2 Target Identification and Validation (pages 43–65): Anthony M. Manning
Chapter 3 In Vitro and In Vivo Assays (pages 67–98): Adam R. Johnson
Chapter 4 Drug Metabolism and Pharmacokinetics in Drug Discovery (pages 99–139): Kimberley Lentz, Joseph Raybon and Michael W. Sinz
Chapter 5 Cardiovascular Drugs (pages 141–204): Drago R. Sliskovic
Chapter 6 Diabetes Drugs (pages 205–243): Ana B. Bueno, Ana M. Castano and Angel Rodriguez
Chapter 7 CNS Drugs (pages 245–286): John A. Lowe
Chapter 8 Cancer Drugs (pages 287–336): Narendra B. Ambhaikar
Chapter 9 Anti?Inflammatory and Immunomodulatory Drugs (pages 337–388): Jeremy J. Edmunds
Chapter 10 Antibacterial Drugs (pages 389–438): Audrey Chan, Jason Cross, Yong He, Blaise Lippa and Dominic Ryan
Chapter 11 Antiviral Drug Discovery (pages 439–515): Nicholas A. Meanwell, Stanley V. D'Andrea, Christopher W. Cianci, Ira B. Dicker, Kap?Sun Yeung, Makonen Belema and Mark Krystal