Drug Testing In Vitro Breakthroughs and Trends in Cell Culture Technology 1st Edition by Uwe Marx ISBN 9783527314881 by Uwe Marx (editor), Volker Sandig (editor) 9783527314881, 3527314881 instant download after payment.

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ISBN 13: 9783527314881
Author: Uwe Marx

Drug Testing In Vitro Breakthroughs and Trends in Cell Culture Technology 1st Table of contents:

Part I: Emerging In-Vitro Culture Technologies

• 1. Intelligent Biomatrices and Engineered Tissue Constructs: In-Vitro Models for Drug Discovery and Toxicity Testing

  • Philip Lazarovici, Mengyan Li, Anat Perets, Mark J. Mondrinos, Shimon Lecht, Christopher D. Koharski, Paul R. Bidez III, Christine M. Finck, and Peter I. Lelkes

• 2. An Overview on Bioreactor Design, Prototyping and Process Control for Reproducible Three-Dimensional Tissue Culture

  • Ralf Pörtner and Christoph Giese

• 3. An Overview on Bioelectronic and Biosensoric Microstructures Supporting High-Content Screening in Cell Cultures

  • Andrea A. Robitzki and Andrée Rothermel

• 4. Novel In-Vitro Exposure Techniques for Toxicity Testing and Biomonitoring of Airborne Contaminants

  • Amanda Hayes, Shahnaz Bakand, and Chris Winder

Part II: Primary Tissues and Cell Lines in Drug Screening/Testing

• 5. Drug Screening Using Cell Lines: Cell Supply, High-Throughput and High-Content Assays

  • Christa Burger, Oliver Pöschke, and Mirek R. Jurzak

• 6. Cell Lines and Primary Tissues for In-Vitro Evaluation of Vaccine Efficacy

  • Anthony Meager

• 7. Designer Cells Derived from Primary Tissue and Designed Cell Lines as a Sustainable Cell Source for Drug Discovery and Safety Assessment

  • Volker Sandig and Ingo Jordan

• 8. How Human Embryonic Stem Cell Research Can Impact In-Vitro Drug Screening Technologies of the Future

  • André Schrattenholz and Martina Klemm

• 9. Availability, Standardization and Safety of Human Cells and Tissues for Drug Screening and Testing

  • Glyn N. Stacey and Thomas Hartung

Part III: Ethical, Regulatory and Commercial Requirements for Drug Testing and Screening on Human Micro-Organoids In Vitro as a Viable Alternative to Animal Testing

• 10. Ethical Environment and Scientific Rationale Towards In-Vitro Alternatives to Animal Testing: Where Are We Going?

  • Horst Spielmann

• 11. Regulatory Acceptance of In-Vitro Methods

  • Franz Oesch

• 12. Scientific Principles and Regulatory Guidelines for the Validation of In Vitro Test Systems

  • Michael O. Schwenk and Franz Oesch

Part IV: The Tremendous Potential of the In-Vitro Drug Evaluation Platform Technology, Using Human Immune Micro-Organoids as a Prime Example

• 13. How Drug Development of the 21st Century Could Benefit from Human Micro-Organoid In-Vitro Technologies
  • Uwe Marx
• 14. Clinical Validation and Prediction of Human Immunotoxicity of New Chemical Entities by In Vitro Exposure of Human Micro-Organoids
  • Uwe Marx, Heike von Laer, Katrin Lehmann, Michael B. Hillebrecht, and Hansjoachim Hertel
• 15. Outlook: Human Micro-Organoids in the Global Market Place
  • Dirk Schara, Uwe Marx, and Peter C. Lang

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