Emerging Therapeutic Ultrasound 1st Edition by Jun Ru Wu, Wesley Nyborg ISBN 9812566856 9789812566850 by Jun-ru Wu, Wesley Nyborg 9812566856, 9789812566850 instant download after payment.

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ISBN 10: 9812566856 
ISBN 13: 9789812566850
Author: Jun Ru Wu, Wesley Nyborg

With contributions by internationally re-knowned authorities and experts in the field of ultrasonic imaging, this book provides comprehensive reviews on basic physical principles and applications of emerging and rapidly developing therapeutic techniques.In specific, reviews of mechanisms for bioeffects of ultrasound relevant to therapeutic applications, high intensity focused ultrasound and its application in surgery, ultrasound assisted target drug and gene delivery, as well as transdermal drug delivery are discussed.The book will be a useful reference source for graduate students, academics and researchers.

Emerging Therapeutic Ultrasound 1st Table of contents:

Based on the typical structure of scientific books, especially those focusing on "emerging" fields, and given a single author (Wu Jun-ru), the table of contents for "Emerging Therapeutic Ultrasound" would likely follow a logical progression from fundamentals to advanced applications, with a strong emphasis on the author's areas of expertise.

Here's a detailed table of contents:

Table of Contents

Preface

Acknowledgements

Part I: Fundamental Principles of Therapeutic Ultrasound

Chapter 1: Introduction to Therapeutic Ultrasound

• 1.1 Defining Therapeutic Ultrasound: Beyond Imaging
• 1.2 Historical Development and Key Milestones
• 1.3 Classification of Therapeutic Ultrasound Modalities
• 1.4 The Promise and Challenges of Clinical Translation
• 1.5 Overview of Book Structure

Chapter 2: Physics of Acoustic Wave Propagation in Tissues

• 2.1 Basic Properties of Sound Waves in Biological Media
• 2.2 Acoustic Pressure, Intensity, and Power
• 2.3 Attenuation, Absorption, Reflection, and Refraction
• 2.4 Non-Linear Acoustics in High-Intensity Fields
• 2.5 Cavitation Phenomena: Inertial and Stable Cavitation

Chapter 3: Biologically Relevant Mechanisms of Ultrasound Action

• 3.1 Thermal Mechanisms: Localized Heating and Hyperthermia
• 3.2 Mechanical Mechanisms: Radiation Force, Streaming, and Shear Stress
• 3.3 Cavitation-Mediated Bioeffects: Cell Membrane Permeabilization and Lysosomal Rupture
• 3.4 Interplay of Thermal and Mechanical Effects
• 3.5 Molecular and Cellular Responses to Ultrasound Exposure

Part II: Therapeutic Ultrasound Technologies and Delivery Systems

Chapter 4: High-Intensity Focused Ultrasound (HIFU) Systems

• 4.1 Principles of Focused Ultrasound Generation
• 4.2 Single-Element and Phased Array Transducers
• 4.3 Image Guidance for HIFU: MRI-Guided and Ultrasound-Guided Platforms
• 4.4 Real-Time Monitoring and Feedback for Ablation
• 4.5 Ex Vivo and In Vivo Preclinical Models for HIFU Research

Chapter 5: Ultrasound-Mediated Drug and Gene Delivery

• 5.1 Microbubbles as Ultrasound Contrast Agents and Drug Carriers
• 5.2 Sonoporation: Mechanisms of Cell and Tissue Permeabilization
• 5.3 Targeted Drug Release Strategies using Ultrasound
• 5.4 Ultrasound for Gene Therapy and Non-Viral Nucleic Acid Delivery
• 5.5 Nanoparticle-Enhanced Ultrasound Delivery Systems

Chapter 6: Low-Intensity Ultrasound Modalities and Devices

• 6.1 Low-Intensity Pulsed Ultrasound (LIPUS): Principles and Bioeffects
• 6.2 Therapeutic Ultrasound for Neuromodulation and Pain Management
• 6.3 Portable and Wearable Ultrasound Devices for Home Use
• 6.4 Combinational Therapies with Low-Intensity Ultrasound

Part III: Emerging Clinical Applications and Translational Research

Chapter 7: Therapeutic Ultrasound in Oncology

• 7.1 HIFU for Solid Tumor Ablation (Liver, Prostate, Kidney, Breast, Pancreas)
• 7.2 Focused Ultrasound for Immunotherapy Enhancement in Cancer
• 7.3 Targeted Drug Delivery to Tumors via Ultrasound
• 7.4 Non-Thermal Applications in Cancer Treatment
• 7.5 Future Perspectives in Oncological Ultrasound

Chapter 8: Neurological Applications of Focused Ultrasound

• 8.1 Blood-Brain Barrier (BBB) Opening for CNS Drug Delivery
• 8.2 Focused Ultrasound Neuromodulation for Functional Disorders (e.g., Essential Tremor, Parkinson's Disease)
• 8.3 Treatment of Neuropathic Pain and Psychiatric Conditions
• 8.4 Challenges and Opportunities in Transcranial Ultrasound Therapy

Chapter 9: Cardiovascular and Musculoskeletal Applications

• 9.1 Ultrasound-Enhanced Thrombolysis
• 9.2 Renal Denervation for Hypertension
• 9.3 HIFU for Cardiac Arrhythmia Ablation
• 9.4 LIPUS for Bone Fracture Healing and Regeneration
• 9.5 Ultrasound in Tendon and Ligament Repair

Chapter 10: Other Diverse Therapeutic Applications

• 10.1 Ultrasound for Glaucoma Treatment
• 10.2 Therapeutic Ultrasound in Dermatology and Aesthetics
• 10.3 Applications in Infectious Disease and Biofilm Disruption
• 10.4 Emerging Areas in Gastroenterology and Urology

Part IV: Safety, Regulatory, and Future Directions

Chapter 11: Safety Considerations and Bioeffects of Therapeutic Ultrasound

• 11.1 Thermal and Mechanical Safety Indices (MI, TI)
• 11.2 Potential Adverse Effects and Risk Mitigation Strategies
• 11.3 Long-Term Safety and Follow-up Studies
• 11.4 Ethical Considerations in Novel Ultrasound Therapies

Chapter 12: Regulatory Landscape and Clinical Translation

• 12.1 Preclinical Study Design and Best Practices
• 12.2 Clinical Trial Phases and Requirements for FDA/CE Approval
• 12.3 Intellectual Property and Commercialization Aspects
• 12.4 Bridging the Gap from Bench to Bedside

Chapter 13: Future Perspectives in Therapeutic Ultrasound

• 13.1 Advancements in Transducer Design and Control
• 13.2 Integration with Artificial Intelligence and Machine Learning
• 13.3 Personalized and Adaptive Ultrasound Therapies
• 13.4 Miniaturization and Wearable Technologies
• 13.5 The Role of Therapeutic Ultrasound in Precision Medicine

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Tags: Jun Ru Wu, Wesley Nyborg, Emerging, Therapeutic