Enzyme Kinetics In Drug Metabolism Fundamentals And Applications 1st Edition Swati Nagar by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie (eds.) 9781627037570, 9781627037587, 1627037578, 1627037586 instant download after payment.

This book is divided into five parts. Part I provides the fundamental principles of enzyme kinetics. How are these parameters derived? While these are fundamental concepts dealt with in other texts, what do they really mean from a drug metabolism and transport perspective? This book aims at answering this question. Part II of the book focuses on the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters. Part III considers some modeling approaches for both drug metabolizing enzymes and transporters. Understanding of variability—intrinsic and extrinsic—is dealt with in Part IV and is considered crucial from “design of experiments” to “interpretation of results.” Finally in Part V, case studies provide real-life examples, conversations between supervisor and scientist, and current outlooks, which provide opportunities from which we can all learn.