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ISBN 10: 0120342553
ISBN 13: 9780120342556
Author: Frances H. Arnold
This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution.
Chapter 1. New Functions from Old Scaffolds: How Nature Reengineers Enzymes for New Functions
Chapter 2. Evolution of Protein Function by Domain Swapping
Chapter 3. Rational Evolutionary Design: The Theory of In Vitro Protein Evolution
Chapter 4. Temperature Adaptation of Enzymes: Lessons from Laboratory Evolution
Chapter 5. Structural Analysis of Affinity Matured Antibodies and Laboratory-Evolved Enzymes
Chapter 6. Molecular Breeding: The Natural Approach to Protein Design
Chapter 7. Analysis of Large Libraries of Protein Mutants Using Flow Cytometry
Chapter 8. From Catalytic Asymmetric Synthesis to the Transcriptional Regulation of Genes: In Vivo and In Vitro Selection
Chapter 9. In Vitro Selection and Evolution of Proteins
Author Index
Subject Index
evolution of proteins
evolutionary process
protein structure evolution
protein comparisons evolution
an evolutionary perspective
an evolutionary anthropological perspective on modern human origins
Tags: Frances H Arnold, Evolutionary, Approaches, Protein, Design, Volume 55
