Gene Therapy Treating Disease by Repairing Genes 1st Edition by Ph D Panno, Joseph ISBN 0816049483 9780816049486 by Joseph, Ph.d. Panno 0816049483, 9780816049486 instant download after payment.

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Product details:

ISBN 10: 0816049483 
ISBN 13: 9780816049486
Author: Ph D  Panno, Joseph

Gene Therapy Treating Disease by Repairing Genes 1st Table of contents:

• Chapter 1: What is Life? The Basics of Cells and Genetics

  • Introduction to cells and their functions
  • DNA, genes, and chromosomes: The blueprint of life
  • Proteins: The workers of the cell
  • Genetic mutations and their consequences
  • Hereditary diseases

• Chapter 2: The Promise of Gene Therapy

  • What is gene therapy?
  • How gene therapy aims to correct genetic defects
  • The potential to treat previously incurable diseases
  • A brief history of gene therapy research

• Chapter 3: Tools and Techniques of Gene Therapy

  • Vectors:
    • Viral vectors (adenoviruses, retroviruses, adeno-associated viruses, lentiviruses)
    • Non-viral vectors (liposomes, nanoparticles, direct DNA injection)
  • Gene Editing Technologies: (This chapter might cover early gene editing concepts, as CRISPR was not widely known at the book's publication. It might discuss concepts leading to it or more general gene modification.)
    • Gene augmentation/replacement
    • Gene silencing
    • Gene correction
  • How genes are delivered to target cells
  • Laboratory techniques involved

• Chapter 4: Diseases Targeted by Gene Therapy

  • Monogenic Disorders:
    • Cystic Fibrosis
    • Severe Combined Immunodeficiency (SCID) – with a focus on case studies like Ashi DeSilva
    • Hemophilia
    • Muscular Dystrophy
  • Complex Diseases:
    • Cancer
    • AIDS (HIV infection)
    • Cardiovascular diseases
  • Other potential applications

• Chapter 5: Early Trials, Successes, and Setbacks

  • Review of notable early gene therapy trials
  • Discussion of successes and the challenges faced
  • The tragic case of Jesse Gelsinger and its impact on the field
  • Lessons learned from early clinical trials

• Chapter 6: Ethical and Societal Issues

  • Who decides who receives gene therapy?
  • The cost of gene therapy
  • Germline vs. Somatic gene therapy
  • Designer babies and enhancement concerns
  • Safety and long-term effects
  • Public perception and understanding of gene therapy

• Chapter 7: The Future of Gene Therapy

  • New research directions
  • Emerging technologies (e.g., more precise gene editing methods, though CRISPR would come later)
  • Hope for future treatments
  • The regulatory landscape

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Tags: Ph D Panno, Joseph, Gene, Therapy