Genetics Of Autoimmunity Novartis Foundation Symposium 267 Novartis Foundationeds by Novartis Foundation(eds.) 9780470021378, 9780470021392, 0470021373, 047002139X instant download after payment.

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.
Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:
* descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific
* discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.Content:
Chapter 1 Chair's Introduction (page 1): Abul Abbas
Chapter 2 Patterns of Genetic Variation in Humans and Mice (pages 2–13): Mark Daly
Chapter 3 Haplotype Tagging in Pharmacogenetics (pages 14–30): David B. Goldstein
Chapter 4 Multiple Sclerosis: A Haplotype Association Study (pages 31–45): Simon J. Foote, Justin P. Rubio, Melanie Bahlo, Trevor J. Kilpatrick, Terence P. Speed, Jim Stankovich, Rachel Burfoot, Helmut Butzkueven, Laura Johnson, Chris Wilkinson, Bruce Taylor, Michele Sale, Ingrid A. F. van der Mei, Joanne L. Dickinson and Patricia Groom
Chapter 5 Mapping Genes for Asthma and Psoriasis (pages 46–56): Juha Kere
Chapter 6 Natural Genetic Variants Influencing Type 1 Diabetes in Humans and in the NOD Mouse (pages 57–75): Linda S. Wicker, Carolyn L. Moule, Heather Fraser, Carlos Penha?Goncalves, Dan Rainbow, Valerie E. S. Garner, Giselle Chamberlain, Kara Hunter, Sarah Howlett, Jan Clark, Andrea Gonzalez?Munoz, Anne Marie Cumiskey, Paul Tiffen, Joanna Howson, Barry Healy, Luc J. Smink, Amanda Kingsnorth, Paul A. Lyons, Simon Gregory, Jane Rogers, John A. Todd and Laurence B. Peterson
Chapter 7 The Importance of Epistatic Interactions in the Development of Autoimmunity (pages 76–93): Srividya Subramanian and Edward K. Wakeland
Chapter 8 Mapping Autoimmune Disease Genes in Humans: Lessons from IBD and SLE (pages 94–112): Timothy J. Vyse, Angela M. Richardson, Emily Walsh, Lisa Farwell, Mark J. Daly, Cox Terhorst and John D. Rioux
Chapter 9 A Combined Genetics and Genomics Approach to Unravelling Molecular Pathways in Coeliac Disease (pages 113–144): Martin C. Wapenaar and Cisca Wijmenga
Chapter 10 Progress towards Understanding the Genetic Pathogenesis of Systemic Lupus Erythematosus (pages 145–164): Timothy W. Behrens, Robert R. Graham, Chieko Kyogoku, Emily C. Baechler, Paula S. Ramos, Clarence Gillett, Jason Bauer, Ward A. Ortmann, Keli L. Hippen, Erik Peterson, Carl D. Langefeld, Kathy L. Moser, Patrick M. Gaffney and Peter K. Gregersen
Chapter 11 A Molecular Dissection of Lymphocyte Unresponsiveness Induced by Sustained Calcium Signalling (pages 165–179): Vigo Heissmeyer, Fernando Macia, Rajat Varma, Sin?Hyeog Im, Francisco Garcia?Cozar, Heidi F. Horton, Michael C. Byrne, Stefan Feske, K. Venuprasad, Hua Gu, Yun?Cai Liu, Michael L. Dustin and Anjana Rao
Chapter 12 Genetic Lesions in Thymic T Cell Clonal Deletion and Thresholds for Autoimmunity (pages 180–199): Adrian Liston and Christopher C. Goodnow
Chapter 13 An Autoimmune Disease?Associated CTLA4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells (pages 200–218): Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illes, Dan Rainbow, Laurence B. Peterson, Arlene S. Sharpe, Linda S. Wicker and Vijay K. Kuchroo
Chapter 14 Large?Scale Screens for cDNAs with in vivo Activity (pages 219–230): Adrian Ting, Stefan Lichtenthaler, Ramnik Xavier, Soon?Young Na, Shahrooz Rabizadeh, Tara Holmes and Brian Seed
Chapter 15 Genomic Mining of New Genes and Pathways in Innate and Adaptive Immunity (pages 231–241): Jenny Ting