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68 reviewsCrop production is drastically affected due to external or environmental stresses. The biotic stresses cause significant yield losses in the range of 31–42% together with 6–20% loss during the post-harvest stage. The abiotic stresses also aggravate the situation with crop damage in the range of 6–20%. Understanding the mech- anisms of interaction of plants with the biotic stresses caused by insects, bacteria, fungi, viruses, oomycetes, etc., and abiotic stresses due to heat, cold, drought, flooding, submergence, salinity, acidity, etc., is critical to develop resilient crop varieties. Global warming and climate change are also causing emergence of new diseases and insects together with newer biotypes and physiological races of the causal agents on the one hand and aggravating the abiotic stress problems with additional extremes and unpredictability. Development of crop varieties resistant and/or adaptive to these stresses is highly important.