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92 reviewsABSTRACTKeywords:Atopic dermatitis (AD) and psoriasis are chronic skin diseases with a global impact, posing significant challengesGut microbiotato public health systems and severely affecting patients’ quality of life. This review delves into the key role of theAtopic dermatitisgut microbiota in these diseases, emphasizing the importance of the gut-skin axis in inflammatory mediators andPsoriasisimmune regulation and revealing a complex bidirectional communication system. We comprehensively assessedSkin-gut axisthe pathogenesis, clinical manifestations, and treatment strategies for AD and psoriasis, with a particular focus onImmune regulationhow the gut microbiota and their metabolites influence disease progression via the gut-skin axis. In addition,Microbiome-targeted therapypersonalized treatment plans based on individual patient microbiome characteristics have been proposed, ofInflammatory mediatorsfering new perspectives for future treatment approaches. We call for enhanced interdisciplinary cooperation toMetabolic productsfurther explore the interactions between gut microbiota and skin diseases and to assess the potential of drugs andnatural products in modulating the gut-skin axis, aiming to advance the treatment of skin diseases.
