Handbook on White Matter Structure Function and Changes 1st Edition by Timothy B Westland, Robert N Calton ISBN 1607410346 9781607410348 by Timothy B. Westland, Robert N. Calton 9781607410348, 1607410346 instant download after payment.

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Product details:

ISBN 10: 1607410346 
ISBN 13: 9781607410348
Author: Timothy B Westland, Robert N Calton 

Handbook on White Matter Structure Function and Changes 1st Table of contents:

Part I: Fundamental Structure and Development of White Matter

• Chapter 1: Myelin: Formation, Composition, and Diversity
  • Oligodendrocytes and Schwann Cells: Myelin-Forming Glia
  • Molecular Composition of Myelin (Lipids, Proteins)
  • Axon-Glia Interactions
  • Regional Differences in Myelin
• Chapter 2: Axonal Organization and Connectivity
  • Axonal Bundles and Tracts: Macro- and Micro-Structure
  • Node of Ranvier and Paranodal Regions
  • White Matter Topography and Fiber Tracking Principles
  • The Connectome: White Matter as the Brain's Network
• Chapter 3: Developmental Myelination
  • Stages of Myelination Across the Lifespan
  • Genetic and Environmental Influences on Myelination
  • Critical Periods in White Matter Development
  • Developmental Disorders Affecting Myelin

Part II: White Matter Function and Physiology

• Chapter 4: The Role of White Matter in Neural Communication
  • Speed and Efficiency of Conduction (Saltatory Conduction)
  • Synchrony and Information Processing
  • Beyond Conduction: Active Roles of Glia in Information Processing
• Chapter 5: White Matter Plasticity and Learning
  • Experience-Dependent Myelination and De-myelination
  • Plasticity of Axons and Oligodendrocytes
  • White Matter Changes in Skill Learning and Expertise
• Chapter 6: White Matter and Cognition
  • Connectivity and Cognitive Functions (e.g., Executive Function, Memory, Attention)
  • Role in Brain Networks and Large-Scale Cognition
  • Cognitive Correlates of White Matter Microstructure

Part III: White Matter Changes in Health and Disease

• Chapter 7: Aging and White Matter
  • Age-Related Changes in Myelin and Axons
  • Impact on Cognitive Decline
  • Strategies for Maintaining White Matter Health in Aging
• Chapter 8: White Matter in Neurodegenerative Diseases
  • Alzheimer's Disease and Related Dementias
  • Parkinson's Disease
  • Amyotrophic Lateral Sclerosis (ALS)
  • White Matter Pathology and Neurodegeneration
• Chapter 9: Demyelinating and Dysmyelinating Diseases
  • Multiple Sclerosis (MS): Pathophysiology, Diagnosis, Treatment
  • Leukodystrophies: Genetic Disorders of Myelin
  • Other Acquired Demyelinating Syndromes
• Chapter 10: White Matter in Psychiatric and Neurodevelopmental Disorders
  • Schizophrenia and Psychosis
  • Autism Spectrum Disorder (ASD)
  • Attention-Deficit/Hyperactivity Disorder (ADHD)
  • Depression and Anxiety
  • The "Disconnection Hypothesis"
• Chapter 11: Traumatic Brain Injury (TBI) and White Matter
  • Mechanisms of Axonal Injury in TBI
  • Long-Term Consequences of White Matter Damage
  • Imaging and Biomarkers of TBI
• Chapter 12: Cerebrovascular Disease and White Matter
  • Ischemic White Matter Lesions
  • Impact of Small Vessel Disease
  • Lacunar Infarcts and Stroke Recovery

Part IV: Advanced Methodologies for Studying White Matter

• Chapter 13: Diffusion Magnetic Resonance Imaging (dMRI)
  • Principles of Diffusion Tensor Imaging (DTI)
  • Advanced Diffusion Models (e.g., NODDI, Multi-shell dMRI)
  • Fiber Tracking and Tractography
  • Limitations and Challenges of dMRI
• Chapter 14: Quantitative MRI Techniques for Myelin and Axons
  • Myelin Water Imaging (MWI)
  • Magnetization Transfer Imaging (MTI)
  • Proton Density Mapping
  • Correlating MRI with Histology
• Chapter 15: Histological and Microscopic Techniques
  • Myelin Stains and Immunostaining
  • Electron Microscopy of Myelinated Axons
  • Confocal and Live Imaging of Oligodendrocytes and Myelin
• Chapter 16: Genetic and Molecular Approaches
  • Targeted Gene Knockouts and Transgenics
  • Optogenetics and Chemogenetics in White Matter Research
  • Single-Cell RNA Sequencing of Glial Cells
  • Omics Approaches to Myelin Biology

Part V: Therapeutic Strategies and Future Directions

• Chapter 17: Remyelination Strategies

  • Promoting Oligodendrocyte Precursor Cell (OPC) Differentiation
  • Pharmacological Approaches to Remyelination
  • Cell-Based Therapies

• Chapter 18: Neuroprotection and Axon Regeneration

  • Protecting Axons from Degeneration
  • Facilitating Axonal Repair

• Chapter 19: The Future of White Matter Research

  • Translational Research and Clinical Applications
  • Big Data and Artificial Intelligen

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