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4.3
18 reviewsHazard assessment of EO has involved consideration of the chemical composition, characteristics, and reactivity of this material. In spite of the readiness with which EO is transformed within the body to ethylene glycol and ethylene chlorohydrin, EO— with a biological half-life of about 10 min—is distributed throughout most organs of the body. It is an alkylating agent, reacting with cellular macromolecules such as DNA, RNA, and protein, including globin of hemoglobin. By virtue of the formation of chloroacetaldehyde from chlorethanol, EO shares some metabolic pathways with vinyl chloride, although quantitatively these pathways are likely to account for only a small proportion of the total biotransformation of EO.
