Health Effects Of The Use Of Nonsugar Sweeteners Primera Magali Riosleyvraz Jason Montez by Magali Rios-leyvraz; Jason Montez 9789240046429, 9240046429 instant download after payment.

A 2019 systematic review on intake of non-sugar sweeteners (NSS) in adults and children was updated and expanded to include studies in which NSS were not specified by name and studies of effects of NSS on pregnant women published through July 2021. A total of 283 studies were included in the review. Meta-analyses focused on randomized controlled trials, prospective cohort studies and case–control studies assessing cancer, and certainty in results was assessed via GRADE (Grading of Recommendations Assessment, Development and Evaluation). Results for key outcomes in adults (including pregnant women) are summarized in the figure below. In 
addition, a single randomized controlled trial conducted in children reported decreases in several 
measures of adiposity, but no significant effects or associations were observed in meta-analyses.
Consumption of free sugars has been linked to escalating rates of overweight and obesity, as well as development of diet-related noncommunicable diseases (NCDs), including dental caries, type 2 diabetes, cardiovascular diseases and cancer.
As part of global efforts to stem the tide of obesity and diet-related NCDs, the World Health Organization (WHO) has issued guidance on intake of sugars, recommending that intake be significantly reduced. With the current focus on reducing intake of free sugars, interest in 
non-sugar sweeteners (NSS) as a possible alternative has intensified.