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ISBN 10: 0443070989
ISBN 13: 978-0443070983
Author: Charles A. Janeway, Paul Travers, Mark Walport, Mark J. Shlomchik
The central thesis of this book is that the immune system exists to protect the host from infection and that its evolutionary history was shaped by this challenge. Other aspects of immunology (for example allergy, graft rejection etc) are variations on the basic protective function. The first part of the book summarises the basic immunological concepts and introduces the main "players". The middle three parts deal with main aspects of adaptive immunity. The last part integrates the material at the level of the complete organism in both health and disease.
Part I. An Introduction to Immunobiology and Innate Immunity
1. Basic Concepts in Immunology
2. Innate Immunity
Part II. The Recognition of Antigen
3. Antigen Recognition by B-cell and T-cell Receptors
4. The Generation of Lymphocyte Antigen Receptors
5. Antigen Presentation to T Lymphocytes
Part III. The Development of Mature Lymphocyte Receptors Repertoires
6. Signaling Through Immune System Receptors
7. The Development and Survival of Lymphocytes
Part IV. The Adaptive Immune Response
8. T Cell-Mediated Immunity
9. The Humoral Immune Response
10. Adaptive Immunity to Infection
Part V. The Immune System in Health and Disease
11. Failures of Host Defense Mechanisms
12. Allergy and Hypersensitivity
13. Autoimmunity and Transplantation
14. Manipulation of the Immune Response
* Afterword: Evolution of the Immune System: Past, Present and Future
* Appendix I. Immunologists' Toolbox
* Appendix II. CD Antigens
* Appendix III. Cytokines and their Receptors
* Appendix IV. Chemokines and their Receptors
* Appendix V. Immunological Constants
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Tags: Charles A Janeway, Paul Travers, Mark Walport, Mark J Shlomchik, Immunobiology, Immune System, Health, Disease