Immunological Synapse 1st Edition by Takashi Saito, Facundo D Batista ISBN 364226185X 9783642261855 by Michael L. Dustin (auth.), Takashi Saito, Facundo D. Batista (eds.) 9783642038570, 3642038573 instant download after payment.

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ISBN 10: 364226185X 
ISBN 13: 9783642261855
Author: Takashi Saito, Facundo D Batista

Immunological Synapse 1st Table of contents:

Part I: Foundations and Historical Perspective

• Chapter 1: Introduction to the Immunological Synapse
  • 1.1 Definition and Early Observations
  • 1.2 The Concept of "Synapse" in Biology (Neuronal vs. Immunological)
  • 1.3 Key Players: T Cells, APCs, NK Cells, B Cells
  • 1.4 Historical Development of the Immunological Synapse Model
  • 1.5 Overview of Functions: Activation, Differentiation, Memory, Cytotoxicity
• Chapter 2: Core Molecules and Their Initial Interactions
  • 2.1 T Cell Receptor (TCR) Complex: Structure and Ligand Recognition
  • 2.2 Major Histocompatibility Complex (MHC) Molecules (Class I and II)
  • 2.3 Co-stimulatory Molecules (CD28/B7, CD2/LFA-3, LFA-1/ICAM-1)
  • 2.4 Adhesion Molecules and Their Roles in Cell Contact (Integrins, Cadherins)
  • 2.5 Cytokines and Chemokines in Early Recruitment and Signaling

Part II: Formation and Structure of the Immunological Synapse

• Chapter 3: Dynamics of Synapse Formation
  • 3.1 Initial Cell-Cell Contact and Adhesion
  • 3.2 Receptor-Ligand Binding and Microcluster Formation
  • 3.3 Peripheral Supramolecular Activation Cluster (pSMAC)
  • 3.4 Central Supramolecular Activation Cluster (cSMAC)
  • 3.5 Distinguishing cSMAC from pSMAC: Molecular Composition and Function
  • 3.6 Role of the Cytoskeleton (Actin and Microtubules) in Synapse Reorganization
• Chapter 4: Molecular Organization of the Synapse
  • 4.1 The Bullseye Model and Its Evolution
  • 4.2 Lipid Rafts and Membrane Microdomains in Synapse Assembly
  • 4.3 Protein-Protein Interactions within Synaptic Microclusters
  • 4.4 Exclusion of Large Molecules (CD45) from the cSMAC
  • 4.5 Force Generation and Mechano-sensing at the Synapse

Part III: Signaling and Functional Outcomes

• Chapter 5: TCR Signaling Pathways at the Synapse
  • 5.1 Early Signaling Events: Lck, ZAP-70, LAT
  • 5.2 Downstream Signaling Cascades (MAPK, PLCγ1, NFAT, NF-κB)
  • 5.3 Spatiotemporal Control of Signaling within the Synapse
  • 5.4 Negative Regulation of TCR Signaling
• Chapter 6: Co-stimulation and Co-inhibition at the Synapse
  • 6.1 Integrating Signals from Co-stimulatory Receptors (e.g., CD28, ICOS)
  • 6.2 The Role of Co-inhibitory Receptors (e.g., CTLA-4, PD-1) in Immune Checkpoints
  • 6.3 Fine-Tuning T Cell Activation and Tolerance
• Chapter 7: Cytokine Secretion and Directed Release
  • 7.1 Polarization of the Secretory Pathway towards the Synapse
  • 7.2 Directed Release of Cytokines (e.g., IL-2, IFN-γ)
  • 7.3 Role of the Golgi Apparatus and Microtubule Organizing Center (MTOC)
• Chapter 8: Cytotoxic Synapse and Killer Cell Functions
  • 8.1 Formation of the Cytotoxic Synapse by CTLs and NK Cells
  • 8.2 Directed Delivery of Cytotoxic Granules (Perforin, Granzymes)
  • 8.3 Mechanisms of Target Cell Killing (Apoptosis Induction)
  • 8.4 Granzyme Uptake and Mechanisms in Target Cells
  • 8.5 The Role of FasL/Fas Pathway

Part IV: Diverse Immunological Synapses and Their Contexts

• Chapter 9: B Cell Synapse and Antigen Presentation
  • 9.1 Antigen Recognition by B Cell Receptor (BCR)
  • 9.2 B Cell-T Cell Interaction and Cognate Help
  • 9.3 The B Cell Synapse: Similarities and Differences to T Cell Synapse
  • 9.4 Antigen Extraction and Processing at the B Cell Synapse
• Chapter 10: Regulatory T Cell (Treg) Synapse
  • 10.1 Mechanisms of Immune Suppression by Tregs
  • 10.2 Molecular Components of the Treg Synapse
  • 10.3 How Tregs Deliver Suppressive Signals to Effector T Cells
• Chapter 11: Macrophage and Dendritic Cell Synapses
  • 11.1 Interactions of Phagocytes with Lymphocytes
  • 11.2 Formation of Specialized Synapses for Antigen Presentation
  • 11.3 Bidirectional Signaling in Macrophage/DC-T Cell Interactions
• Chapter 12: Synapses in Vivo: Imaging and Physiological Relevance
  • 12.1 Intravital Microscopy and Live-Cell Imaging of Synapses
  • 12.2 Synapse Formation in Lymphoid Organs (Lymph Nodes, Spleen)
  • 12.3 Role of the Synapse in Immune Surveillance and Disease Pathogenesis

Part V: Clinical Implications and Future Directions

• Chapter 13: Immunological Synapse in Disease
  • 13.1 Autoimmune Diseases (e.g., Type 1 Diabetes, Rheumatoid Arthritis)
  • 13.2 Cancer Immunotherapy (Targeting Immune Checkpoints)
  • 13.3 Viral Infections and Immune Evasion
  • 13.4 Allergic Reactions and Hypersensitivity
• Chapter 14: Therapeutic Targeting of the Immunological Synapse
  • 14.1 Modulating Co-stimulatory/Co-inhibitory Pathways
  • 14.2 Engineering T Cells for Adoptive Cell Therapy (CAR T Cells)
  • 14.3 Vaccine Design and Optimizing Immune Responses
  • 14.4 Small Molecule Inhibitors Targeting Synaptic Signaling
• Chapter 15: Emerging Concepts and Future Technologies
  • 15.1 Beyond the Planar Synapse: 3D Interactions and Niches
  • 15.2 Systems Biology Approaches to Synaptic Signaling
  • 15.3 Single-Cell Resolution Studies of Synapse Formation
  • 15.4 Advances in Imaging Techniques
  • 15.5 Future Challenges and Research Opportunities

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