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Impact Of Survivin Acetylation On Its Biological Function 1st Edition David Dannheisig Auth

  • SKU: BELL-5885858
Impact Of Survivin Acetylation On Its Biological Function 1st Edition David Dannheisig Auth
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Impact Of Survivin Acetylation On Its Biological Function 1st Edition David Dannheisig Auth instant download after payment.

Publisher: Springer Spektrum
File Extension: PDF
File size: 6.05 MB
Pages: 120
Author: David Dannheisig (auth.)
ISBN: 9783658186227, 9783658186234, 3658186224, 3658186232
Language: English
Year: 2017
Edition: 1

Product desciption

Impact Of Survivin Acetylation On Its Biological Function 1st Edition David Dannheisig Auth by David Dannheisig (auth.) 9783658186227, 9783658186234, 3658186224, 3658186232 instant download after payment.

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.

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