Inhibitors Of Molecular Chaperones As Therapeutic Agents Timothy D Machajewski by Timothy D Machajewski, Zhenhai Gao, David Rotella, Didier Picard, Chrisostomos Prodromou, Lila Gierasch, Paul Workman, Marco Biamonte, Weiwen Ying, Tim Haystead, Michael Ruggard-jensen, Brian Blagg, Wenlai Zhou, Len Neckers, Emin Avsar, Utpal Tatu, Pamela 9781849736664, 1849736669 instant download after payment.

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.