Intravascular Delivery Of An Ultraflexible Neural Electrode Array For Recordings Of Cortical Spiking Activity Xingzhao Wang Shun Wu Hantao Yang Yu Bao Zhi Li Changchun Gan Yuanyuan Deng Junyan Cao Xue Li Yun Wang Chi Ren Zhigang Yang Zhengtuo Zhao by Xingzhao Wang & Shun Wu & Hantao Yang & Yu Bao & Zhi Li & Changchun Gan & Yuanyuan Deng & Junyan Cao & Xue Li & Yun Wang & Chi Ren & Zhigang Yang & Zhengtuo Zhao instant download after payment.

Although intracranial neural electrodes have significantly contributed to bothfundamental research and clinical treatment of neurological diseases, theirimplantation requires invasive surgery to open craniotomies, which canintroduce brain damage and disrupt normal brain functions. Recent emergence of endovascular neural devices offers minimally invasive approaches forneural recording and stimulation. However, existing endovascular neuraldevices are unable to resolve single-unit activity in large animal models orhuman patients, impeding a broader application as neural interfaces in clinicalpractice. Here, we present the ultraflexible implantable neural electrode as anintravascular device (uFINE-I) for recording brain activity at single-unit resolution. We successfully implanted uFINE-Is into the sheep occipital lobe bypenetrating through the confluence of sinuses and recorded both local fieldpotentials (LFPs) and multi-channel single-unit spiking activity under spontaneous and visually evoked conditions. Imaging and histological analysisrevealed minimal tissue damage and immune response. The uFINE-I provides apractical solution for achieving high-resolution neural recording with minimalinvasiveness and can be readily transferred to clinical settings for future neuralinterface applications such as brain-machine interfaces (BMIs) and the treatment of neurological diseases.