Investigative Electrocardiography in Epidemiological Studies and Clinical Trials 1st Edition by Pentti Rautaharju, Farida Rautaharju ISBN 1447159624 9781447159629 by Pentti Rautaharju, Farida Rautaharju, 1846284651, 9781846284656 instant download after payment.

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Product details:

ISBN 10: 1447159624

ISBN 13: 9781447159629

Author: Pentti Rautaharju, Farida Rautaharju 

This book on investigative electrocardiography is addressed to investigators who are using electrocardiology as a research tool in epidemiological or clinical research or in investigations on possible adverse responses of new pharmacological agents. The primary emphasis of the book is on prognostic implications of ECG abnormalities in the conditions covered, including the prevalence and incidence of ECG abnormalities in contrasting populations. We excluded from our book cardiac disorders with a relatively low population pre- lence that otherwise may be of great clinical interest. We also decided to exclude acute myocardial infarction because we had only limited resources available on this topic from our population studies and from those clinical trials in which we have personally p- ticipated in the classi? cation of trial endpoints within the framework of an ECG research center. Clinical trials are a relatively new area of electrocardiology. However, electrocard- graphy has become a most valuable research tool in clinical trials and in investigations on morbidity and mortality risk associated with various clinical and subclinical con- tions. It has also become a crucial research tool in investigating adverse cardiac events associated with administration of new drugs. Evaluation of QT prolongation plays a central role in these investigations. As a possible marker of malignant arrhythmias, it is used by regulating agencies in their decision process for approval of new pharmacolo- cal agents.

Table of contents:

1. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials

2. Cardiac Excitation and Repolarization

3. Electrocardiographic Lead Systems

4. Normal and Arrhythmogenic Ionic Channel Mechanism

5. Heart Rate and Heart Rate Variability

6. Methodological Considerations in Heart Rate Variability Analysis

7. Supraventricular Dysrhythmias

8. Ectopic Ventricular Activity

9. Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs

10. Left Ventricular Hypertrophy

11. Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage

12. Prolonged Ventricular Excitation

13. Old Myocardial Infarction

14. Attributable Risk

15. Primary Repolarization Abnormalities

16. Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements

17. QT Prolongation and QT Dispersion — a Critical Evaluation

18. Normal ECG Standards for Adults by Gender, Age, and Ethnicity

19. ECG Intervals: Tables

20. ECG Wave Amplitudes: Tables

21. ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables

22. ECG Amplitudes at 10ms Intervals: Tables

23. Repolarization Waveform Vectors: Tables

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Tags: Pentti Rautaharju, Farida Rautaharju, Investigative Electrocardiography, Epidemiological Studies, Clinical Trials