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Lead Generation Approaches In Drug Discovery Zoran Rankovic Richard Morphy

  • SKU: BELL-4307200
Lead Generation Approaches In Drug Discovery Zoran Rankovic Richard Morphy
$ 31.00 $ 45.00 (-31%)

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Lead Generation Approaches In Drug Discovery Zoran Rankovic Richard Morphy instant download after payment.

Publisher: Wiley
File Extension: PDF
File size: 5.88 MB
Pages: 297
Author: Zoran Rankovic, Richard Morphy
ISBN: 9780470257616, 9780470584170, 047025761X, 0470584173
Language: English
Year: 2010

Product desciption

Lead Generation Approaches In Drug Discovery Zoran Rankovic Richard Morphy by Zoran Rankovic, Richard Morphy 9780470257616, 9780470584170, 047025761X, 0470584173 instant download after payment.

An integrated overview of modern approaches to lead discovery

Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:

  • The evolution of the lead discovery process, key concepts, current challenges, and future directions

  • Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process

  • Knowledge-based in silico or "virtual" screening

  • Theory and practice of the fragment-based approach to lead discovery

  • The opportunities and challenges presented by multi-target drug discovery (MTDD)

  • De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules

  • The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space

  • Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery

  • The utility of parallel synthesis and purification in lead discovery

With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.Content:
Chapter 1 Lead Discovery: The Process (pages 1–19): William F. Michne
Chapter 2 High Throughput Screening Approach to Lead Discovery (pages 21–71): Zoran Rankovic, Craig Jamieson and Richard Morphy
Chapter 3 In Silico Screening (pages 73–103): Dagmar Stumpfe, Hanna Geppert and Jurgen Bajorath
Chapter 4 Fragment?Based Lead Discovery (pages 105–139): Jeffrey S. Albert
Chapter 5 Design of Multitarget Ligands (pages 141–164): Richard Morphy and Zoran Rankovic
Chapter 6 De novo Drug Design (pages 165–185): Gisbert Schneider, Markus Hartenfeller and Ewgenij Proschak
Chapter 7 Role of Natural Products in Drug Discovery (pages 187–229): Hugo Lachance, Stefan Wetzel and Herbert Waldmann
Chapter 8 Early Screening for ADMET Properties (pages 231–258): Dennis A. Smith
Chapter 9 Role of Chemistry in Lead Discovery (pages 259–290): Roland E. Dolle and Karin Worm

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