Metalloproteomics Eugene A Permyakovauth Vladimir N Uverskyeds by Eugene A. Permyakov(auth.), Vladimir N. Uversky(eds.) 0470392487, 0470447753, 9780470392485, 9780470447758 instant download after payment.

Synthesizes the current knowledge in the field and provides new insights into medical applications

Metalloproteomics is the large-scale study of metal-binding proteins. These proteins, which represent about one quarter of all the proteins in the Protein Data Bank, play important roles in all biological systems and all biological processes. Metalloproteomics provides the latest information on all major families of metal-binding proteins, including their structural, physico-chemical, and functional properties, enabling readers to better understand these proteins. Moreover, the book demonstrates how understanding the structures, properties, and functions of intracellular and extracellular metal-binding proteins may unlock the key to drug development for the treatment of a myriad of diseases.

Written by Eugene Permyakov, an international expert and pioneer in the structural analysis of metal-binding proteins, the book offers

• Theoretical introduction to cation binding

• Broad range of methods for investigating the binding of different cations to proteins

• Characteristics of interactions of physiologically important cations of Ca, Mg, Zn, Fe, Mn, Co, Cu, Ni, Mo, W, Na, and K with proteins

• Detailed considerations of structural and physico-chemical properties of the metal-binding proteins

• Interactions of all other metal cations with proteins

• Interactions of different types of cations with nucleic acids

Throughout the text, the author integrates principles of proteomics. In addition, detailed examples underscore the role metal-binding proteins play in health and medicine.

Bringing together and analyzing all the latest findings, Metalloproteomics' scope and level of insight are unparalleled. It is recommended for biophysicists, biochemists, enzymologists, cell and molecular biologists, protein and peptide scientists, organic and bioinorganic chemists, and chemical biologists.

Content:
Chapter 1 Complexes of Metal Cations and Low?Molecular?Mass Compounds and of Metal Cations and Proteins (pages 7–19):
Chapter 2 General Regularities of the Binding of Metal Cations to Proteins (pages 21–36):
Chapter 3 Experimental Methods Used for Studies of the Binding of Metal Cations (pages 37–58):
Chapter 4 Calcium, Calcium?Binding Proteins, and their Major Families (pages 59–186):
Chapter 5 Interactions of Calcium?Binding Proteins with Low?Molecular?Mass Compounds, Peptides, Proteins, and Membranes (pages 187–229):
Chapter 6 Calcium?Binding Proteins in Various Systems (pages 231–273):
Chapter 7 The Binding of Magnesium Ions to Proteins (pages 275–281):
Chapter 8 The Binding of Zinc Ions to Proteins (pages 283–338):
Chapter 9 The Binding of Copper Ions to Proteins (pages 339–388):
Chapter 10 Iron?Binding Proteins (pages 389–451):
Chapter 11 Molybdenum?Containing and Tungsten?Containing Proteins (pages 453–465):
Chapter 12 Proteins Containing Nickel and Cobalt (pages 467–477):
Chapter 13 Manganese?Containing Proteins (pages 479–489):
Chapter 14 Sodium?Binding and Potassium?Binding Proteins (pages 491–520):
Chapter 15 Interactions of Metal Cations with Nucleic Acids (pages 521–531):
Chapter 16 “Nonphysiologic” Metals (pages 533–639):
Chapter 17 Concluding Remarks (pages 641–642):