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Microbial Pathogenomics 1st Edition by Hilde de Reuse, S Bereswill ISBN 9783805591928

  • SKU: BELL-2106854
Microbial Pathogenomics 1st Edition by Hilde de Reuse, S Bereswill ISBN 9783805591928
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Microbial Pathogenomics 1st Edition by Hilde de Reuse, S Bereswill ISBN 9783805591928 instant download after payment.

Publisher: S. Karger AG (Switzerland)
File Extension: PDF
File size: 6.79 MB
Pages: 222
Author: Hilde de Reuse, S. Bereswill
ISBN: 3805591926
Language: English
Year: 2009
Edition: 1

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Microbial Pathogenomics 1st Edition by Hilde de Reuse, S Bereswill ISBN 9783805591928 by Hilde De Reuse, S. Bereswill 3805591926 instant download after payment.

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ISBN 13: 9783805591928
Author: Hilde de Reuse, S Bereswill

'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'. 'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.

Microbial Pathogenomics 1st Table of contents:

Part I: Genomic Technologies and Concepts in Pathogenomics

  • Chapter 1: Genome Comparison of Bacterial Pathogens
    • By T.M. Wassenaar, J. Bohlin, T.T. Binnewies, and D.W. Ussery
    • (Likely covers methodologies and tools for comparing bacterial genomes to identify virulence factors, evolutionary relationships, etc.)
  • Chapter 2: In Silico Reconstruction of the Metabolic and Pathogenic Potential of Bacterial [Pathogens]
    • (Focuses on computational approaches to predict metabolic pathways and virulence from genomic data.)
  • Chapter 3: The Bacterial Pan-Genome and Reverse Vaccinology
    • By H. Tettelin
    • (Introduces the concept of pan-genomics, encompassing the entire gene repertoire of a bacterial species, and its application in vaccine development.)
  • Chapter 4: 'Guilty by Association' – Protein-Protein Interactions (PPIs) in Bacterial Virulence
    • (Explores how interactomics helps understand virulence mechanisms by studying protein interactions.)

Part II: Pathogen-Specific Genomic Insights and Case Studies

  • Chapter 5: Helicobacter pylori Sequences Reflect Past Human Migrations
    • By Y. Moodley and B. Linz
    • (Examines the co-evolution of H. pylori with human populations through genomic analysis.)
  • Chapter 6: Helicobacter pylori Genome Plasticity
    • By D.A. Baltrus, M.J. Blaser, and K. Guillemin
    • (Delves into the mechanisms and implications of genomic variations in H. pylori.)
  • Chapter 7: Genomics of Thermophilic Campylobacter Species
    • By D.J.H. Gaskin, M. Reuter, N. Shearer, F. Mulholland, B.M. Pearson, and A.H.M. van Vliet
    • (Focuses on the genomic characteristics of heat-tolerant Campylobacter species.)
  • Chapter 8: Adaptation of Pathogenic E. coli to Various Niches: Genome Flexibility is the Key
    • (Discusses how E. coli adapts to different host environments through genomic changes.)
  • Chapter 9: Role of Horizontal Gene Transfer in the Evolution of Pseudomonas aeruginosa
    • (Examines the significant impact of horizontal gene transfer on the evolution and pathogenicity of P. aeruginosa.)
  • Chapter 10: The Genus Burkholderia: Analysis of 56 Genomic Sequences
    • By D.W. Ussery, K. Kiil, K. Lagesen, T. Sicheritz-Pontén, J. Bohlin, and T.M. Wassenaar
    • (A large-scale genomic analysis of the diverse Burkholderia genus.)
  • Chapter 11: Genomics of Host-Restricted Pathogens of the Genus Bartonella
    • By P. Engel and C. Dehio
    • (Focuses on the genomic adaptations that lead to host specificity in Bartonella species.)
  • Chapter 12: Legionella pneumophila – Host Interactions: Insights Gained from Comparative Genomics
    • (Utilizes comparative genomics to understand how Legionella interacts with its hosts.)
  • Chapter 13: A Proteomics View of Virulence Factors of Staphylococcus aureus
    • By S. Engelmann and M. Hecker
    • (Explores virulence factors of S. aureus using proteomic approaches.)
  • Chapter 14: Pathogenomics of Mycobacteria
    • By M.C. Gutierrez, P. Supply, and R. Br

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Tags: Hilde de Reuse, S Bereswill, Microbial, Pathogenomics

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